Mechanisms of Virus Replication and Gene Expression

病毒复制和基因表达机制

• 批准号: 8484338
• 负责人: Anne Elizabeth Simon
• 金额: $ 16.8万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8484338
• 关键词: Gene Expression; Virus Replication

Research in Virology requires more than a focused understanding of human pathogens. It requires comprehensive knowledge of viruses that infect hosts ranging from simple eukaryotes to complex multicellular organisms. A more comprehensive understanding ofthe breadth of Virology promises to provide the tools needed to control perplexing and devastating diseases in humans, as well as animals and plants. Substantive steps in knowledge acquisition require programs that prepare students to synthesize data from diverse systems, including model systems. The systems studied by University of Maryland Virology Program members include such important human pathogens as HIV, influenza, papillomavirus, poxvirus. West Nile, caliciviruses, as well as prions, viroids, fungal hypoviruses, and the model plant viruses Tobacco mosaic virus and Turnip crinkle virus. At the core of our training program are 14 well-funded investigators recognized as leaders in their fields from the Department of Cell Biology and Molecular Genetics, Maryland-Virginia Regional Vet Medicine, University of Maryland Biotechnology Institute Center for Biosystems Research, NIH, NCI, and USDA. Our faculty bring an extraordinarily broad range of expertise, from cellular and molecular biology to genomics and evolution, and from biochemistry to nanotechnology and vaccine development Trainees progress through innovative rotations, advanced courses in molecular and cellular biology, signal transduction, virology, and pathogenesis, journal clubs, attend monthly group meetings and a yearly retreat This training, along with state-of-the-art research projects, prepare trainees for careers centered on combating current and emerging viruses that threaten human health. This renewal application requests financial support for five graduate student traineeships. By combining this support with funds available through grants and intramural funds, over 20 pre-doctoral students will be trained in a five year period. The requested support will focus on attracting incoming students and students in their final years. We are committed to offering this exceptional training experience to highly-motivated students, with a special outreach to minorities, who will greatly enrich the potential for a global public health impact. RELEVANCE (See instructions): Viruses infect nearly all life forms, are responsible for some human cancers, and are devastative disease agents that can cause world-wide pandemics. When properly harnessed, viruses can also be powerful research tools for dissecting cellular processes. This training proposal seeks continued support for training virologists prepared to meet research challenges common to all viruses- which include developing strategies to protect humans, animals, and niants from viral di.seases to imnrovfi the nualitv nf nennle's lives.

病毒学研究需要的不仅仅是对人类病原体的集中了解。它需要 对感染宿主的病毒的全面了解，从简单的真核生物到复杂的多细胞生物 有机体。对病毒学广度的更全面了解有望提供工具 控制人类以及动物和植物中令人困惑和毁灭性的疾病所需。实质性 知识获取的步骤需要让学生准备好综合来自不同系统的数据的程序， 包括模型系统。马里兰大学病毒学项目成员研究的系统包括 艾滋病毒、流感、乳头瘤病毒、痘病毒等重要的人类病原体。西尼罗河病毒、杯状病毒以及 朊病毒、类病毒、真菌低病毒和模式植物病毒烟草花叶病毒和芜菁皱病毒。 我们培训计划的核心是 14 名资金雄厚的研究人员，他们被公认为各自领域的领导者 马里兰-弗吉尼亚地区兽医医学大学细胞生物学和分子遗传学系 马里兰生物技术研究所生物系统研究中心、NIH、NCI 和 USDA。我们的教师带来了 极其广泛的专业知识，从细胞和分子生物学到基因组学和进化，以及 从生物化学到纳米技术和疫苗开发学员通过创新轮换取得进步， 分子和细胞生物学、信号转导、病毒学和发病机制高级课程，期刊 俱乐部，参加每月的小组会议和每年的静修会这种培训以及最先进的研究 项目，为学员做好以抗击威胁人类的当前和新兴病毒为中心的职业生涯的准备 健康。该续签申请要求为五名研究生实习提供财政支持。通过结合 通过赠款和校内基金提供的资金支持，将有 20 多名博士前学生 为期五年的培训。所请求的支持将侧重于吸引新生和在校学生 他们的最后几年。我们致力于为积极主动的学生提供这种卓越的培训体验， 对少数群体进行特别宣传，将极大地丰富其对全球公共卫生影响的潜力。 相关性（参见说明）： 病毒几乎感染所有生命形式，导致一些人类癌症，并且是毁灭性的疾病 可能引起世界范围流行病的病原体。如果利用得当，病毒也可以变得强大 用于剖析细胞过程的研究工具。本培训提案寻求对培训的持续支持 病毒学家准备应对所有病毒共同的研究挑战，其中包括制定策略 保护人类、动物和婴儿免受病毒性疾病的侵害，从而改善人们的生活。

项目成果

Rootstock-induced scion resistance against tobacco mosaic virus is associated with the induction of defence-related transcripts and graft-transmissible mRNAs.

• DOI: 10.1111/mpp.13353
• 发表时间: 2023-09
• 期刊: MOLECULAR PLANT PATHOLOGY
• 影响因子: 4.9
• 作者: Kappagantu, Madhu;Brandon, Matthew;Tamukong, Yvette B.;Culver, James N.
• 通讯作者: Culver, James N.

Dynamic changes impact the plum pox virus population structure during leaf and bud development.

• DOI: 10.1016/j.virol.2020.06.014
• 发表时间: 2020-09
• 期刊: Virology
• 影响因子: 3.7
• 作者: Tamukong YB;Collum TD;Stone AL;Kappagantu M;Sherman DJ;Rogers EE;Dardick C;Culver JN
• 通讯作者: Culver JN

Multiple Cis-acting elements modulate programmed -1 ribosomal frameshifting in Pea enation mosaic virus.

• DOI: 10.1093/nar/gkv1241
• 发表时间: 2016-01-29
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Gao F;Simon AE
• 通讯作者: Simon AE

Shiftless Is a Novel Member of the Ribosome Stress Surveillance Machinery That Has Evolved to Play a Role in Innate Immunity and Cancer Surveillance.

• DOI: 10.3390/v15122296
• 发表时间: 2023-11-23
• 期刊: Viruses
• 作者: Kelly JA;Dinman JD
• 通讯作者: Dinman JD

Position of the kissing-loop interaction associated with PTE-type 3'CITEs can affect enhancement of cap-independent translation.

• DOI: 10.1016/j.virol.2014.03.027
• 发表时间: 2014-06
• 期刊: VIROLOGY
• 影响因子: 3.7
• 作者: Chattopadhyay, Maitreyi;Kuhlmann, Micki M.;Kumar, Kalyani;Simon, Anne E.
• 通讯作者: Simon, Anne E.