Mechanisms of Virus Replication and Gene Expression

病毒学研究需要的不仅仅是对人类病原体的重点了解。它需要 全面了解感染宿主的病毒，从简单的真核细胞到复杂的多细胞 有机体。对病毒学广度的更全面的理解有望提供工具 需要控制人类以及动植物中令人费解和毁灭性的疾病。实质性的 知识获取的步骤要求学生准备好综合来自不同系统的数据， 包括模型系统。马里兰大学病毒学项目成员研究的系统包括 人类重要的病原体，如艾滋病毒、流感、乳头瘤病毒、痘病毒。西尼罗河，杯状病毒，以及 Pron，类病毒，真菌低病毒，以及模式植物病毒烟草花叶病毒和芜菁皱纹病毒。 我们培训计划的核心是14名资金雄厚的调查人员，他们被公认为各自领域的领导者 马里兰-弗吉尼亚地区兽医，马里兰大学细胞生物学和分子遗传学系 马里兰生物技术研究所生物系统研究中心，NIH，NCI和美国农业部。我们的教职员工带来了 非常广泛的专业知识，从细胞和分子生物学到基因组学和进化，以及 从生物化学到纳米技术和疫苗开发学员通过创新轮换取得进展， 分子和细胞生物学、信号转导、病毒学和发病机制高级课程 俱乐部，参加每月的小组会议和每年的静修培训，以及最先进的研究 项目，使受训人员为以抗击威胁人类的当前和新兴病毒为中心的职业做好准备 健康。这份续签申请要求为五个研究生实习生职位提供财政支持。通过组合 这项支持通过助学金和校内基金提供资金，将有20多名博士前学生 培训为期五年。所要求的支持将集中在吸引新生和 他们生命的最后几年。我们致力于为积极进取的学生提供这一非凡的培训体验， 通过对少数群体的特别宣传，他们将极大地丰富对全球公共卫生产生影响的潜力。 相关性(请参阅说明)： 病毒感染几乎所有的生命形式，是一些人类癌症的罪魁祸首，是毁灭性的疾病 可能导致全球大流行的病原体。如果控制得当，病毒也可以是强大的。 解剖细胞过程的研究工具。本培训计划寻求对培训的持续支持 病毒学家准备迎接所有病毒共同的研究挑战--包括制定策略 以保护人类、动物和动物免受病毒感染，从而影响他们的生活。

Research in Virology requires more than a focused understanding of human pathogens. It requires comprehensive knowledge of viruses that infect hosts ranging from simple eukaryotes to complex multicellular organisms. A more comprehensive understanding ofthe breadth of Virology promises to provide the tools needed to control perplexing and devastating diseases in humans, as well as animals and plants. Substantive steps in knowledge acquisition require programs that prepare students to synthesize data from diverse systems, including model systems. The systems studied by University of Maryland Virology Program members include such important human pathogens as HIV, influenza, papillomavirus, poxvirus. West Nile, caliciviruses, as well as prions, viroids, fungal hypoviruses, and the model plant viruses Tobacco mosaic virus and Turnip crinkle virus. At the core of our training program are 14 well-funded investigators recognized as leaders in their fields from the Department of Cell Biology and Molecular Genetics, Maryland-Virginia Regional Vet Medicine, University of Maryland Biotechnology Institute Center for Biosystems Research, NIH, NCI, and USDA. Our faculty bring an extraordinarily broad range of expertise, from cellular and molecular biology to genomics and evolution, and from biochemistry to nanotechnology and vaccine development Trainees progress through innovative rotations, advanced courses in molecular and cellular biology, signal transduction, virology, and pathogenesis, journal clubs, attend monthly group meetings and a yearly retreat This training, along with state-of-the-art research projects, prepare trainees for careers centered on combating current and emerging viruses that threaten human health. This renewal application requests financial support for five graduate student traineeships. By combining this support with funds available through grants and intramural funds, over 20 pre-doctoral students will be trained in a five year period. The requested support will focus on attracting incoming students and students in their final years. We are committed to offering this exceptional training experience to highly-motivated students, with a special outreach to minorities, who will greatly enrich the potential for a global public health impact. RELEVANCE (See instructions): Viruses infect nearly all life forms, are responsible for some human cancers, and are devastative disease agents that can cause world-wide pandemics. When properly harnessed, viruses can also be powerful research tools for dissecting cellular processes. This training proposal seeks continued support for training virologists prepared to meet research challenges common to all viruses- which include developing strategies to protect humans, animals, and niants from viral di.seases to imnrovfi the nualitv nf nennle's lives.