Mechanisms of Virus Replication and Gene Expression

病毒学研究需要的不仅仅是对人类病原体的集中了解。它需要 病毒感染宿主的全面知识，从简单的真核生物到复杂的多细胞生物 有机体更全面地了解病毒学的广度， 需要控制人类以及动物和植物的复杂和毁灭性疾病。实质性 知识获取的步骤需要让学生准备好综合来自不同系统的数据的程序， 包括模型系统。马里兰州大学病毒学项目成员研究的系统包括 这些重要的人类病原体如艾滋病毒、流感、乳头瘤病毒、痘病毒。西尼罗河病毒，杯状病毒，以及 朊病毒、类病毒、真菌低病毒和模式植物病毒烟草花叶病毒和芜菁皱缩病毒。 我们培训计划的核心是14名资金充足的调查人员，他们被公认为各自领域的领导者，来自 马里兰-弗吉尼亚州兽医大学细胞生物学和分子遗传学系 马里兰州生物技术研究所生物系统研究中心、NIH、NCI和USDA。我们的教师带来了一个 从细胞和分子生物学到基因组学和进化， 从生物化学到纳米技术和疫苗开发受训人员通过创新的轮换取得进展， 分子与细胞生物学、信号传导、病毒学与发病机理高级教程 俱乐部，参加每月的小组会议和每年的务虚会。这项培训，沿着最先进的研究 项目，准备学员的职业生涯集中在打击当前和新出现的病毒，威胁人类 健康此更新申请要求五个研究生实习的财政支持。通过组合 通过赠款和校内基金提供资金支持，将有20多名博士前学生 在五年的时间里训练。所要求的支持将侧重于吸引即将入学的学生和 他们的最后几年我们致力于为积极进取的学生提供这种特殊的培训体验， 世卫组织特别针对少数群体开展外联活动，这将极大地丰富其对全球公共卫生产生影响的潜力。 相关性（参见说明）： 病毒感染几乎所有的生命形式，是导致一些人类癌症的原因，并且是一种恶性疾病。 能引起全球性传染病的病原体如果利用得当，病毒也可以很强大 用于解剖细胞过程的研究工具。本培训提案寻求对培训的持续支持 病毒学家准备迎接所有病毒共同的研究挑战，包括制定战略 保护人类，动物和婴儿免受病毒感染，以保护他们的生命。

Research in Virology requires more than a focused understanding of human pathogens. It requires comprehensive knowledge of viruses that infect hosts ranging from simple eukaryotes to complex multicellular organisms. A more comprehensive understanding ofthe breadth of Virology promises to provide the tools needed to control perplexing and devastating diseases in humans, as well as animals and plants. Substantive steps in knowledge acquisition require programs that prepare students to synthesize data from diverse systems, including model systems. The systems studied by University of Maryland Virology Program members include such important human pathogens as HIV, influenza, papillomavirus, poxvirus. West Nile, caliciviruses, as well as prions, viroids, fungal hypoviruses, and the model plant viruses Tobacco mosaic virus and Turnip crinkle virus. At the core of our training program are 14 well-funded investigators recognized as leaders in their fields from the Department of Cell Biology and Molecular Genetics, Maryland-Virginia Regional Vet Medicine, University of Maryland Biotechnology Institute Center for Biosystems Research, NIH, NCI, and USDA. Our faculty bring an extraordinarily broad range of expertise, from cellular and molecular biology to genomics and evolution, and from biochemistry to nanotechnology and vaccine development Trainees progress through innovative rotations, advanced courses in molecular and cellular biology, signal transduction, virology, and pathogenesis, journal clubs, attend monthly group meetings and a yearly retreat This training, along with state-of-the-art research projects, prepare trainees for careers centered on combating current and emerging viruses that threaten human health. This renewal application requests financial support for five graduate student traineeships. By combining this support with funds available through grants and intramural funds, over 20 pre-doctoral students will be trained in a five year period. The requested support will focus on attracting incoming students and students in their final years. We are committed to offering this exceptional training experience to highly-motivated students, with a special outreach to minorities, who will greatly enrich the potential for a global public health impact. RELEVANCE (See instructions): Viruses infect nearly all life forms, are responsible for some human cancers, and are devastative disease agents that can cause world-wide pandemics. When properly harnessed, viruses can also be powerful research tools for dissecting cellular processes. This training proposal seeks continued support for training virologists prepared to meet research challenges common to all viruses- which include developing strategies to protect humans, animals, and niants from viral di.seases to imnrovfi the nualitv nf nennle's lives.