Mechanisms of Virus Replication and Gene Expression

病毒复制和基因表达机制

• 批准号: 7903936
• 负责人: Anne Elizabeth Simon
• 金额: $ 17.46万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7903936
• 关键词: Gene Expression; Virus Replication

DESCRIPTION (provided by applicant): Research in Virology requires more than a focused understanding of human pathogens. It requires comprehensive knowledge of viruses that infect hosts ranging from simple eukaryotes to complex multicellular organisms. A more comprehensive understanding of the breadth of Virology promises to provide the tools needed to control perplexing and devastating diseases in humans, as well as animals and plants. Substantive steps in knowledge acquisition require programs that prepare students to synthesize data from diverse systems, including model systems. The systems studied by University of Maryland Virology Program members include such important human pathogens as HIV, influenza, papillomavirus, poxvirus. West Nile, caliciviruses, as well as prions, viroids, fungal hypoviruses, and the model plant viruses Tobacco mosaic virus and Turnip crinkle virus. At the core of our training program are 14 well-funded investigators recognized as leaders in their fields from the Department of Cell Biology and Molecular Genetics, Maryland-Virginia Regional Vet Medicine, University of Maryland Biotechnology Institute Center for Biosystems Research, NIH, NCI, and USDA. Our faculty bring an extraordinarily broad range of expertise, from cellular and molecular biology to genomics and evolution, and from biochemistry to nanotechnology and vaccine development Trainees progress through innovative rotations, advanced courses in molecular and cellular biology, signal transduction, virology, and pathogenesis, journal clubs, attend monthly group meetings and a yearly retreat This training, along with state-of-the-art research projects, prepare trainees for careers centered on combating current and emerging viruses that threaten human health. This renewal application requests financial support for five graduate student traineeships. By combining this support with funds available through grants and intramural funds, over 20 pre-doctoral students will be trained in a five year period. The requested support will focus on attracting incoming students and students in their final years. We are committed to offering this exceptional training experience to highly-motivated students, with a special outreach to minorities, who will greatly enrich the potential for a global public health impact. RELEVANCE: Viruses infect nearly all life forms, are responsible for some human cancers, and are devastative disease agents that can cause world-wide pandemics. When properly harnessed, viruses can also be powerful research tools for dissecting cellular processes. This training proposal seeks continued support for training virologists prepared to meet research challenges common to all viruses- which include developing strategies to protect humans, animals, and plants from viral diseases to improve the quality of people's lives.

描述（由申请人提供）：病毒学研究需要的不仅仅是对人类病原体的集中理解。它需要对感染宿主（从简单的真核生物到复杂的多细胞生物）的病毒有全面的了解。更全面地了解病毒学的广度，有望为控制人类以及动物和植物中令人困惑和毁灭性的疾病提供所需的工具。知识获取的实质性步骤要求课程让学生准备好综合来自不同系统的数据，包括模型系统。马里兰大学病毒学项目成员研究的系统包括HIV、流感、乳头瘤病毒、痘病毒等重要的人类病原体。西尼罗河病毒，杯状病毒，以及朊病毒，类病毒，真菌次病毒，和模式植物病毒烟草花叶病毒和萝卜皱病毒。我们培训计划的核心是来自细胞生物学和分子遗传学、马里兰-弗吉尼亚地区兽医医学、马里兰大学生物技术研究所生物系统研究中心、NIH、NCI和USDA的14名资金雄厚的研究人员，他们在各自的领域被公认为领导者。我们的教师带来了非常广泛的专业知识，从细胞和分子生物学到基因组学和进化，从生物化学到纳米技术和疫苗开发，学员通过创新的轮转，分子和细胞生物学，信号转导，病毒学和发病机制的高级课程，期刊俱乐部，参加每月的小组会议和每年的静修来进步。培养学员从事以防治威胁人类健康的当前和新出现的病毒为中心的职业。这份续期申请要求为五名研究生实习提供财政支持。通过将这种支持与通过赠款和校内基金提供的资金相结合，将在五年内培训20多名博士预科学生。所要求的支持将侧重于吸引新生和即将毕业的学生。我们致力于向上进心强的学生提供这种特殊的培训经验，并特别向少数民族伸出援助之手，他们将大大丰富对全球公共卫生产生影响的潜力。