Genetic and Epigenetic Studies of Aging

描述（来自应用程序）：此项目的长期目标 该计划项目是了解参与的基本分子机制， 人类细胞衰老具体目标是：（1）汇集六个 使用不同的细胞衰老模型系统的各个实验室： 正常人成纤维细胞、肾上腺皮质细胞和黑素细胞，各种 永生的人类细胞系和动物模型;共同研究类似的 目标，使用常见的技术和方法来回答有关 衰老的分子和细胞机制， 永生这些研究将检查基因表达的变化 在体外和体内老化的细胞中发生， 导致细胞抑制的途径的差异和相似之处 增殖认识到老龄化是一个多方面的过程， 个别项目将探讨与年龄有关的变化的各种机制， 基因表达，包括DNA甲基化，染色质结构，衰老 特异性反式激活因子和RNA结合蛋白， 从体外到体内老化。2)提供必要的核心设施 所有项目，从而整合资源， 以更低的成本进行研究。因此，项目的目标将是 满足，鼓励成功的互动和加强利用 共同资源。3)提供促进研究的正式机制 通过联合规划会议进行互动。

DESCRIPTION (from the application): The long range goal of this program project is to understand the basic molecular mechanisms involved in human cellular senescence. The specific aims are to: 1) Bring together six individual laboratories using disparate model systems of cellular senescence: normal human fibroblasts, adrenocortical cells and melanocytes, various immortal human cell lines and animal models; to work together on similar goals, using common techniques and approaches to answer questions regarding the molecular and cellular mechanisms involved in senescence and immortalization. These studies will examine the changes in gene expression that occur in cells as they age in vitro and in vivo, and will establish the differences and similarities in the pathways that lead to inhibition of cell proliferation. Recognizing that aging is a multi-faceted process, the individual projects will explore various mechanisms of age related changes in gene expression, including DNA methylation, chromatic structure, senescence specific transactivating factors and RNA binding proteins and the relevance of in vitro to in vivo aging. 2) Provide core facilities that are requisite for all the projects and thereby consolidate resources that will benefit the research at a much lower cost. The aims of a program project will thereby be met, encouraging successful interactions and enhancing the utilization of common resources. 3) Provide a formal mechanism to promote research interactions via joint planning meetings.