Mechanisms of the Stress-Substance Use Disorder Relation

压力与物质使用障碍关系的机制

• 批准号: 6936817
• 负责人: Kevin Michael King
• 金额: $ 2.83万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6936817
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; behavioral /social science research tag; child rearing; clinical research; conduct disorder; coping; family structure /dynamics; human data; impulsive behavior; interview; longitudinal human study; model design /development; parent offspring interaction; predoctoral investigator; psychological models; psychological stressor; questionnaires; substance abuse epidemiology; substance abuse related disorder; young adult human (21-34)

DESCRIPTION (provided by applicant): The proposed project is designed to test models of the mechanisms by which life stress during adolescence can lead to the development of substance use disorders. Most theoretical models of these mechanisms focus on stress-related increases in internalizing symptoms as being proximal to substance use; yet empirical findings have been mixed. An alternative pathway is proposed, where stressful life events produce elevations in conduct problems and externalizing symptoms, which subsequently leads to substance use disorders by young adulthood. Clarifying how stress during adolescence leads to substance use disorders in young adulthood informs etiological theories and helps to better specify prevention efforts. Aim 1 is to study the mediational roles of externalizing behaviors and internalizing symptoms in the relation between stress and substance use problems and dependence. Aim 2 is to study the moderational role of behavioral under control, supportive parenting and active coping on the above pathways from stress to substance dependence. Utilizing data from a longitudinal, high-risk sample of children of alcoholics and matched controls (N=454), this study is uniquely positioned to address the above issues.

描述（由申请人提供）： 拟议的项目旨在测试青春期生命压力可以导致物质使用障碍发展的机制模型。这些机制的大多数理论模型都集中在与压力相关的症状上增加内在症状的增加，因为近端是使用物质。然而，经验发现混合在一起。提出了一种替代途径，其中压力大的生活事件会导致行为问题和外在症状的升高，随后导致成年后的物质使用障碍。阐明青春期的压力如何导致年轻成年中的物质使用障碍为病因理论提供了信息，并有助于更好地指定预防努力。目的1是研究外在行为的中介作用和在压力和物质使用问题和依赖性之间的关系中的内部症状。目的2是研究在控制，支持性育儿和主动应对上从压力到物质依赖性的上述途径上的主动作用。利用来自戒酒和匹配对照儿童的纵向高危儿童的数据（n = 454），本研究是独特的，可以解决上述问题。