Mechanisms of the Stress-Substance Use Disorder Relation

压力与物质使用障碍关系的机制

• 批准号: 6936817
• 负责人: Kevin Michael King
• 金额: $ 2.83万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6936817
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; behavioral /social science research tag; child rearing; clinical research; conduct disorder; coping; family structure /dynamics; human data; impulsive behavior; interview; longitudinal human study; model design /development; parent offspring interaction; predoctoral investigator; psychological models; psychological stressor; questionnaires; substance abuse epidemiology; substance abuse related disorder; young adult human (21-34)

DESCRIPTION (provided by applicant): The proposed project is designed to test models of the mechanisms by which life stress during adolescence can lead to the development of substance use disorders. Most theoretical models of these mechanisms focus on stress-related increases in internalizing symptoms as being proximal to substance use; yet empirical findings have been mixed. An alternative pathway is proposed, where stressful life events produce elevations in conduct problems and externalizing symptoms, which subsequently leads to substance use disorders by young adulthood. Clarifying how stress during adolescence leads to substance use disorders in young adulthood informs etiological theories and helps to better specify prevention efforts. Aim 1 is to study the mediational roles of externalizing behaviors and internalizing symptoms in the relation between stress and substance use problems and dependence. Aim 2 is to study the moderational role of behavioral under control, supportive parenting and active coping on the above pathways from stress to substance dependence. Utilizing data from a longitudinal, high-risk sample of children of alcoholics and matched controls (N=454), this study is uniquely positioned to address the above issues.

描述（由申请人提供）：