Mechanisms of the Stress-Substance Use Disorder Relation

压力与物质使用障碍关系的机制

• 批准号: 6936817
• 负责人: Kevin Michael King
• 金额: $ 2.83万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6936817
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; behavioral /social science research tag; child rearing; clinical research; conduct disorder; coping; family structure /dynamics; human data; impulsive behavior; interview; longitudinal human study; model design /development; parent offspring interaction; predoctoral investigator; psychological models; psychological stressor; questionnaires; substance abuse epidemiology; substance abuse related disorder; young adult human (21-34)

DESCRIPTION (provided by applicant): The proposed project is designed to test models of the mechanisms by which life stress during adolescence can lead to the development of substance use disorders. Most theoretical models of these mechanisms focus on stress-related increases in internalizing symptoms as being proximal to substance use; yet empirical findings have been mixed. An alternative pathway is proposed, where stressful life events produce elevations in conduct problems and externalizing symptoms, which subsequently leads to substance use disorders by young adulthood. Clarifying how stress during adolescence leads to substance use disorders in young adulthood informs etiological theories and helps to better specify prevention efforts. Aim 1 is to study the mediational roles of externalizing behaviors and internalizing symptoms in the relation between stress and substance use problems and dependence. Aim 2 is to study the moderational role of behavioral under control, supportive parenting and active coping on the above pathways from stress to substance dependence. Utilizing data from a longitudinal, high-risk sample of children of alcoholics and matched controls (N=454), this study is uniquely positioned to address the above issues.

描述（由申请人提供）： 拟议的项目旨在测试青春期生活压力可能导致药物使用障碍发展的机制模型。这些机制的大多数理论模型都集中在与压力相关的内化症状增加，因为它们接近物质使用;但实证研究结果好坏参半。提出了一种替代途径，其中压力的生活事件产生海拔的行为问题和外化症状，随后导致物质使用障碍的青年成年。阐明青春期的压力如何导致青年期的物质使用障碍，为病因学理论提供信息，并有助于更好地具体说明预防工作。目的1研究外化行为和内化症状在应激与物质使用问题和依赖关系中的中介作用。目的二是研究行为控制、支持性父母教养和积极应对在压力向物质依赖转化过程中的调节作用。利用纵向的，高风险的酗酒者和匹配的对照组（N=454）的儿童样本的数据，这项研究是唯一定位，以解决上述问题。