Emergence of Adolescent Substance Use Problems from the Externalizing Spectrum

从外化谱来看青少年药物使用问题的出现

• 批准号: 7935282
• 负责人: Kevin Michael King
• 金额: $ 42.62万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7935282
• 关键词: Address; Adolescence; Adolescent; Adult; Age; Aggressive behavior; Alcohol or Other Drugs use; Alcohols; Antisocial Personality Disorder; Area; Attention; Attention deficit hyperactivity disorder; Behavior; Child; Childhood; Clinical Research; Communities; Conduct Disorder; Data; Data Analyses; Data Reporting; Data Set; Development; Disease; Evaluation; Exhibits; Goals; Growth; Health Care Costs; Hyperactive behavior; Impulsivity; Individual; Intervention; Knowledge; Label; Longevity; Longitudinal Studies; Measurement; Measures; Mediating; Methods; Modeling; Neighborhoods; Oppositional Defiant Disorder; Pathway interactions; Pharmaceutical Preparations; Plant Roots; Prevention; Preventive; Process; Psychometrics; Public Health; Race; Research; Research Priority; Risk; Rural; Sampling; Screening procedure; Structure; Substance Use Disorder; Symptoms; Testing; Time; adolescent substance use; anti social; cost; design; disinhibitory psychopathology; early adolescence; externalizing behavior; high risk; inattention; innovation; insight; kindergarten; prevent; product development; response; sex; teacher

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (04) Clinical Research and Specific Challenge Topic, 04-DA-102: A New Look at Longitudinal Data. Prior research has consistently indicated that adolescents who are at risk for developing substance use disorders exhibit externalizing behavior problems, including higher levels of conduct problems (e.g., oppositional behavior, aggression, delinquency) and attention-deficit/hyperactivity (ADHD) symptoms (i.e., inattention, hyperactivity, impulsivity). Recent research has identified a phenotypic vulnerability to disinhibitory psychopathology, called the externalizing spectrum, which is believed to underlie the development of substance use, problems, and disorder during adolescence and adulthood, and externalizing behavior problems that occur across the lifespan (ADHD, oppositional defiant disorder, conduct disorder, and antisocial personality disorder). Yet developmental models of the externalizing spectrum have not been tested, nor has the emergence of substance use and problems within the externalizing spectrum been examined. Given the public health costs associated with substance use, it is imperative to study the process by which substance use disorders emerge and where, when, or with whom it is possible to intervene in order to prevent the development of substance use problems and disorder. The proposed study will capitalize on an extensive longitudinal data set, the Fast Track project, to examine the relationships between different indicators of the externalizing spectrum from childhood to late adolescence. Fast Track was a multisite, longitudinal study that conducted annual evaluations from kindergarten to age 20 in a community sample of children (n = 754) at high risk for serious conduct problems, who were identified from a screening sample of 9,454 children. The first goal of the proposed research is to use the screening and longitudinal samples to develop a developmentally sensitive model of the externalizing spectrum (including substance use) within three developmental periods (childhood, early adolescence, and late adolescence), with a specific focus on testing whether the psychometric structure of the externalizing spectrum is consistent across time, sex, race, and neighborhood setting (urban vs. rural). The second goal is to test whether the externalizing spectrum can be represented by a single higher-order factor across developmental periods, and to determine whether the underlying externalizing spectrum is best characterized as categorical (i.e., qualitatively distinct pathways of development) or continuous (i.e., continuum of externalizing problems throughout adolescence). Ultimately, the results from these secondary data analyses will provide insight into potential targets for the prevention and treatment of substance use, problems, and disorders. This project will increase understanding of how the "externalizing spectrum" of behaviors is expressed from childhood through late adolescence. It will also examine how substance use, problems, and disorder emerge as part of the externalizing spectrum across this developmental period. This has important implications for designing more effective preventive and treatment interventions for substance use and related problems.

描述（由申请人提供）：此申请介绍了广泛的挑战领域（04）临床研究和特定挑战主题，04-DA-102：纵向数据的新外观。先前的研究始终表明，有可能发展出物质使用障碍风险的青少年表现出外在的行为问题，包括更高水平的行为问题（例如，对立行为，侵略，犯罪）和注意力缺陷/多动症（ADHD）症状（即，不关心，注意力，超级运动，冲动性）。最近的研究已经确定了对抑制性心理病理学的表型脆弱性，称为外部化谱，据信这是在青春期和成年期间的毒品使用，问题和混乱的发展，以及整个生命周期中发生的行为问题（ADHD，对立，反对性挑衅，导致障碍，反应障碍和反社会障碍）。然而，尚未测试外部化光谱的发展模型，也没有检查过外部化频谱中物质使用和问题的出现。鉴于与药物使用相关的公共卫生成本，必须研究出现物质使用障碍以及在哪里，何时或与之进行干预以防止物质使用问题和混乱的过程。拟议的研究将利用广泛的纵向数据集，即快速轨道项目，以检查从儿童期到青春期晚期的外在化频谱的不同指标之间的关系。 Fast Track是一项多站点的纵向研究，在儿童的社区样本（n = 754）中，对严重行为问题的高风险进行了年度评估，从9,454名儿童的筛查样本中鉴定出来。拟议的研究的第一个目标是使用筛查和纵向样本在三个发育时期内（儿童期，青春期和青春期早期）在外部化频谱（包括吸毒）的发育敏感模型中开发出一种发育敏感的模型，并特别着重于测试外部谱系的心理量表是否跨越时间，性爱，性爱，竞赛和竞赛（竞赛和竞赛）（vs. vs. vs. vs. vsse vs.第二个目标是测试外部化频谱是否可以在整个发育周期内由单个高阶因子表示，并确定基本的外部化频谱是最好地表征为分类（即定性不同的发展途径）还是连续的（即在整个青春期内外部化问题的连续性）。最终，这些二级数据分析的结果将为预防和治疗物质使用，问题和疾病的潜在目标提供洞察力。该项目将增加对从童年到青春期晚期表达行为的“外部化频谱”的理解。它还将研究在此发育时期内的物质使用，问题和混乱是如何作为外在化频谱的一部分。这对于设计更有效的预防和治疗干预措施对物质使用和相关问题具有重要意义。