Mechanisms of the Stress-Substance Use Disorder Relation

压力与物质使用障碍关系的机制

• 批准号: 7074035
• 负责人: Kevin Michael King
• 金额: $ 2.83万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7074035
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; behavioral /social science research tag; child rearing; clinical research; conduct disorder; coping; family structure /dynamics; human data; impulsive behavior; interview; longitudinal human study; model design /development; parent offspring interaction; predoctoral investigator; psychological models; psychological stressor; questionnaires; substance abuse epidemiology; substance abuse related disorder; young adult human (21-34)

DESCRIPTION (provided by applicant): The proposed project is designed to test models of the mechanisms by which life stress during adolescence can lead to the development of substance use disorders. Most theoretical models of these mechanisms focus on stress-related increases in internalizing symptoms as being proximal to substance use; yet empirical findings have been mixed. An alternative pathway is proposed, where stressful life events produce elevations in conduct problems and externalizing symptoms, which subsequently leads to substance use disorders by young adulthood. Clarifying how stress during adolescence leads to substance use disorders in young adulthood informs etiological theories and helps to better specify prevention efforts. Aim 1 is to study the mediational roles of externalizing behaviors and internalizing symptoms in the relation between stress and substance use problems and dependence. Aim 2 is to study the moderational role of behavioral under control, supportive parenting and active coping on the above pathways from stress to substance dependence. Utilizing data from a longitudinal, high-risk sample of children of alcoholics and matched controls (N=454), this study is uniquely positioned to address the above issues.

描述(由申请人提供)： 这项拟议的项目旨在测试青春期生活压力可能导致物质使用障碍发展的机制模型。这些机制的大多数理论模型都集中在压力相关的内化症状的增加上，因为内化症状接近于物质使用；然而，经验研究结果喜忧参半。提出了一种替代途径，在这种情况下，应激性生活事件会导致行为问题和外化症状的升高，从而导致年轻人的物质使用障碍。澄清青春期的压力如何导致青春期的物质使用障碍，有助于提供病因学理论，并有助于更好地具体预防措施。目的一是研究外化行为和内化症状在应激与物质使用、问题与依赖关系中的中介作用。目的2研究控制下行为、支持性父母教养方式和积极应对方式在上述应激-物质依赖途径中的调节作用。利用来自酗酒者和配对对照儿童(N=454)的纵向、高风险样本的数据，这项研究独特地定位于解决上述问题。

项目成果

The relation between adolescent substance use and young adult internalizing symptoms: findings from a high-risk longitudinal sample.

青少年物质使用与年轻人内化症状之间的关系：来自高风险纵向样本的发现。

• DOI: 10.1037/0893-164x.21.1.97
• 发表时间: 2007
• 期刊: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
• 作者: Trim,RyanS;Meehan,BarbaraT;King,KevinM;Chassin,Laurie
• 通讯作者: Chassin,Laurie