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Antitumor and Antiviral Nucleoside Analogues

Antitumor and Antiviral Nucleoside Analogues
抗肿瘤和抗病毒核苷类似物
批准号：
7005639
负责人：
JIRI ZEMLICKA
金额：
$20.39万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-07-01 至 2009-04-30
来源：
https://reporter.nih.gov/project-details/7005639
关键词：
aminopurineantineoplasticsantiviral agentscell linechemical structure functioncyclopropanescytomegalovirusdrug design /synthesis /productionenzyme linked immunosorbent assayhepatitis B virus groupherpes simplex virus 1herpes simplex virus 2high performance liquid chromatographyhuman herpesvirus 6human herpesvirus 8human immunodeficiency virusneoplasm /cancernucleic acid hybridizationnucleoside analognucleotide analogphosphonateprodrugsstereoisomerthiophosphate

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英文摘要
DESCRIPTION (provided by applicant): New nucleoside and nucleotide analogues will be prepared and studied as antiviral and antitumor agents. These compounds will include (i) enantiomeric triphosphates and non-hydrolyzable triphosphates of methylenecyclopropanes, (ii) ethynyl methylenecyclopropanes, (iii) fluorinated analogues of gem-bis (hydroxymethyl)methylenecyclopropanes, (iv) tris-(hydroxymethy)methylenecyclopropanes and (v) cyclopropavir phosphonates, acyclic and cyclic. Antiviral activity will be investigated in the following viral assays: Human immunodeficiency virus (HIV), human and murine cytomegalovirus (HCMV and MCMV), herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), human herpes virus 6 and 8 (HHV-6 and HHV-8) and hepatitis B virus (HBV). In vivo activity and mechanism of action of active analogues will also be studied. Selected compounds will also be tested for antitumor activity
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METHYLENECYCLOPROPANE ANALOGS AND PRODRUGS FOR HCMV
METHYLENECYCLOPROPANE ANALOGS AND PRODRUGS FOR HCMV
METHYLENECYCLOPROPANE ANALOGS AND PRODRUGS FOR HCMV
METHYLENECYCLOPROPANE ANALOGS AND PRODRUGS FOR HCMV
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