课题基金 / 基金详情

Antitumor and Antiviral Nucleoside Analogues

Antitumor and Antiviral Nucleoside Analogues
抗肿瘤和抗病毒核苷类似物
批准号：
6640080
负责人：
JIRI ZEMLICKA
金额：
$18.63万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-07-01 至 2005-06-30
来源：
https://reporter.nih.gov/project-details/6640080
关键词：
aminopurine antineoplastics antiviral agents cyclopropanes cytomegalovirus drug design /synthesis /production herpes simplex virus 1 human immunodeficiency virus neoplasm /cancer nucleoside analog prodrugs stereoisomer thiophosphate

项目摘要

项目成果

JIRI ZEMLICKA的其他基金

相似基金

相关文献

中文摘要
翻译
描述(申请人提供)：新的核苷和核苷酸类似物将被制备和研究作为抗病毒抗肿瘤药物。这些化合物将包括(I)gem-bis-(hydroxymethyl)methylenecyclopropanes，(Ii)GEM-双(羟甲基)亚甲基环丙烷的环磷酸盐，(Iii)gem-bis-(hydroxymethyl)methylenecyclopropanes，的亲脂性磷酸丙氨酸酯前药(Iv)7-(2-氨基)嘌呤类似物，(V)亚甲基环丙烷的磷酸盐类似物和(Vi)亚丙氨酸亚甲基环丙烷药物的R和S非对映异构体的拆分，相应的硫代磷酸化合物的合成和细胞内激活的立体化学研究。
英文摘要
DESCRIPTION (provided by applicant): New nucleoside and nucleotide analogues will be prepared and studied as antiviral antitumor agents.These compounds will include (i) gem-bis-(hydroxymethyl)methylenecyclopropanes, (ii) cyclicphosphates of gem-bis-(hydroxymethyl) methylenecyclopropanes, (iii) lipophilic phosphoralaninate prodrugs of gem-bis-(hydroxymethyl)methylenecyclopropanes, (iv) 7-(2-amino)purine analogues, (v) phosphonateanalogues of methylenecyclopropanes and (vi) resolution of R and S diastereoisomers of phosphoralaninate methylenecyclopropane prodrugs,synthesis of the respective phosphorothioates and study of stereochemistry of intracellular activation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
METHYLENECYCLOPROPANE ANALOGS AND PRODRUGS FOR HCMV
METHYLENECYCLOPROPANE ANALOGS AND PRODRUGS FOR HCMV
METHYLENECYCLOPROPANE ANALOGS AND PRODRUGS FOR HCMV
METHYLENECYCLOPROPANE ANALOGS AND PRODRUGS FOR HCMV
海外基金