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Antitumor and Antiviral Nucleoside Analogues

Antitumor and Antiviral Nucleoside Analogues
抗肿瘤和抗病毒核苷类似物
批准号：
6541957
负责人：
JIRI ZEMLICKA
金额：
$21.63万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-07-01 至 2005-06-30
来源：
https://reporter.nih.gov/project-details/6541957
关键词：
aminopurine antineoplastics antiviral agents cyclopropanes cytomegalovirus drug design /synthesis /production herpes simplex virus 1 human immunodeficiency virus neoplasm /cancer nucleoside analog prodrugs stereoisomer thiophosphate

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): New nucleoside and nucleotide analogues will be prepared and studied as antiviral antitumor agents.These compounds will include (i) gem-bis-(hydroxymethyl)methylenecyclopropanes, (ii) cyclicphosphates of gem-bis-(hydroxymethyl) methylenecyclopropanes, (iii) lipophilic phosphoralaninate prodrugs of gem-bis-(hydroxymethyl)methylenecyclopropanes, (iv) 7-(2-amino)purine analogues, (v) phosphonateanalogues of methylenecyclopropanes and (vi) resolution of R and S diastereoisomers of phosphoralaninate methylenecyclopropane prodrugs,synthesis of the respective phosphorothioates and study of stereochemistry of intracellular activation.
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