Antitumor and Antiviral Nucleoside Analogues

描述（由申请人提供）：将制备和研究新的核苷和核苷酸类似物作为抗病毒和抗肿瘤药物。这些化合物将包括(i)亚甲基环丙烷的对映体三磷酸盐和不可水解的三磷酸盐，（ii）乙基亚甲基环丙烷，（iii）双（羟甲基）亚甲基环丙烷的氟化类似物，（iv）三（羟甲基）亚甲基环丙烷和(v)环丙帕韦磷酸盐，无环和环。抗病毒活性将在以下病毒检测中进行调查：人类免疫缺陷病毒（HIV）、人类和小鼠巨细胞病毒（HCMV和MCMV）、单纯疱疹病毒1型和2型（HSV-1和HSV-2）、人类疱疹病毒6和8型（HHV-6和HHV-8）和乙型肝炎病毒（HBV）。活性类似物的体内活性和作用机制也将被研究。选定的化合物还将测试其抗肿瘤活性

DESCRIPTION (provided by applicant): New nucleoside and nucleotide analogues will be prepared and studied as antiviral and antitumor agents. These compounds will include (i) enantiomeric triphosphates and non-hydrolyzable triphosphates of methylenecyclopropanes, (ii) ethynyl methylenecyclopropanes, (iii) fluorinated analogues of gem-bis (hydroxymethyl)methylenecyclopropanes, (iv) tris-(hydroxymethy)methylenecyclopropanes and (v) cyclopropavir phosphonates, acyclic and cyclic. Antiviral activity will be investigated in the following viral assays: Human immunodeficiency virus (HIV), human and murine cytomegalovirus (HCMV and MCMV), herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), human herpes virus 6 and 8 (HHV-6 and HHV-8) and hepatitis B virus (HBV). In vivo activity and mechanism of action of active analogues will also be studied. Selected compounds will also be tested for antitumor activity