IMPROVED PREVENTIVE/RESTORATIVE RESINS AND COMPOSITES

改进的预防/修复树脂和复合材料

• 批准号: 6983252
• 负责人: SABINE H DICKENS
• 金额: $ 18.75万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-07 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6983252
• 关键词: biomaterial development /preparation; biomaterial evaluation; chemical structure; chemical synthesis; composite resins; computer simulation; dental materials; human tissue; hydropathy; liquid chromatography mass spectrometry; model design /development; monomer; nuclear magnetic resonance spectroscopy; restorative dentistry; thin layer chromatography

DESCRIPTION: There is still a need to develop new Dental monomers to overcome the shortcomings that limit the useable lifetime of resin based Dental restorations. Current day resin-based Dental composites have clinical performance deficiencies that include inadequate resistance to wear, secondary caries as a result of marginal leakage, and hydrolytic breakdown of filler-resin interface. Here it is proposed to correlate the chemical core structure of a polymerizable monomer to selected properties in the resulting Dental material. For example, dimethacrylate monomers with rigid aromatic and flexible aliphatic groups will result in polymers with increased toughness, a desired property for improving wear resistance in Dental composites. In this exploratory application we propose to synthesize aromatic acid monomers with varying numbers of rigid aromatic groups and flexible ether linkages interspaced between them. We will then study the influence of these chemical structures on the mechanical and physical properties of the resulting polymers (Aim 1). Analytical methods such as TLC, LC-MS, FTIR, NMR, and others will be used as necessary. Fracture toughness, conversion, water sorption and the viscoelastic properties and glass transition temperature of the polymers will be determined. Computer modeling of the monomers will be carried out to build an empirical correlation between the energy of rotation about the ether linkage and the resulting toughness of the polymer from the synthesized monomers (Aim 2). Molecular features such as the number and bulkiness of the aromatic groups can increase the energy of rotation due to steric hindrances and electronic interactions. The study will also include calculating the resulting energies from changing the ether linkage to e.g., a perfluoro-isopropylidene, carbonyl, or sulfone (-SO2-) group and others. This modeling may indicate which intramolecular features of the monomer are important for controlling the toughness of the polymer. The data gathered in these experiments will serve to support a larger R01 grant application with the long-term objectives of developing improved durable materials for adhesives and adhesive composites.

产品说明：仍然需要开发新的牙科单体以克服限制基于树脂的牙科树脂的可用寿命的缺点。目前的树脂基牙科复合材料具有临床性能缺陷，包括耐磨性不足、边缘渗漏导致的继发性龋齿以及填料-树脂界面的水解分解。在这里，提出了将可聚合单体的化学核心结构与所得牙科材料中的选定性质相关联。例如，具有刚性芳族和柔性脂族基团的二甲基丙烯酸酯单体将导致具有增加的韧性的聚合物，这是用于改善牙科复合材料的耐磨性的期望性质。在这个探索性的应用中，我们建议合成芳香酸单体，它们之间具有不同数量的刚性芳香族基团和柔性醚键。然后，我们将研究这些化学结构对所得聚合物的机械和物理性能的影响（目标1）。必要时将使用分析方法，如TLC、LC-MS、FTIR、NMR等。将测定聚合物的断裂韧性、转化率、吸水性和粘弹性能以及玻璃化转变温度。将进行单体的计算机建模，以建立围绕醚键的旋转能量与合成单体的聚合物的所得韧性之间的经验相关性（目标2）。分子特征，如芳香基团的数量和体积，可以增加由于空间位阻和电子相互作用的旋转能量。该研究还将包括计算将醚键改变为例如，全氟-亚异丙基、羰基或砜（-SO2-）基团等。该建模可以指示单体的哪些分子内特征对于控制聚合物的韧性是重要的。在这些实验中收集的数据将用于支持更大的R 01赠款申请，其长期目标是开发用于粘合剂和粘合剂复合材料的改进的耐用材料。