RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES

产品说明：目标是开发基于树脂的再矿化材料，以改善龋齿的预防和治疗，龋齿是最常见的口腔疾病之一，通常在修复治疗后复发，并在老年人中以根龋的形式发生。一种更保守的治疗龋齿的方法，称为非创伤性修复治疗（ART），这些材料可以应用于其中，最近变得流行起来。 在此，开发了基于树脂的生物活性复合材料，其含有用于释放Ca和P 〇 4离子的磷酸钙（Ca-P 〇 4）填料，并且在适用的情况下，含有用于增强的纤维或晶须，用于超敏反应和各种龋齿相关疾病（例如，预防复发性龋齿。该复合材料含有酸性和其他甲基丙烯酸酯树脂，Ca-PO 4填料和氟化物添加剂（如果需要）。基本组成是密切相关的，在以前资助的工作，这导致了一个高度生物相容性的水泥具有优异的结果时，用作体外产生的牙齿病变的再矿化剂，并作为直接的牙髓盖剂在体内。假设：现有的基于树脂的生物活性复合材料和粘固剂可以被改性以用于其中矿化和龋齿预防能力是最重要的应用。具体目标：1。通过调整现有骨水泥的粘度，同时保持高Ca和PO 4离子释放，再矿化潜力和比玻璃离子水泥更大的强度，开发和测试专门针对ART的体外和原位配方; 2.研制一种可重复使用的根面龋修复材料; 3.开发一种用于牙齿过敏、龋齿修复和预防的缓释生物降解涂层; 4.研制可固化正畸和冠桥粘固剂，并进行正畸粘固剂对牙釉质保护作用的临床研究。这项研究的完成将导致Ca-PO 4水泥和复合材料具有改善的牙本质粘附性和改善的ART和根龋治疗强度。

DESCRIPTION: The goals are to develop resin-based remineralizing materials for improved prevention and treatment of caries, one of the most prevalent oral diseases often recurring after restorative treatment and occurring as root caries in the elderly. A more conservative treatment of caries known as atraumatic restorative treatment (ART), to which these materials could be applied, has recently become popular. Here, resin-based bioactive composites containing calcium phosphate (Ca-PO4) fillers for the release of Ca and P04 ions and, where applicable, fibers or whiskers for reinforcement are developed for the remineralization treatment of hypersensitivity and various caries-related diseases, e.g., the prevention of recurrent caries. The composites contain acidic- and other methacrylate resins, Ca-PO4 fillers and, if indicated fluoride additives. The basic composition is closely related to those described in previously funded work, which led to a highly biocompatible cement with excellent results when used as a remineralizing agent for in vitro generated tooth lesions and as a direct pulp-capping agent in vivo. Hypothesis: Existing resin-based bioactive composites and cements can be modified for applications, where remineralizing and caries preventive capabilities are of greatest importance. Specific Aims: 1. Develop and test in vitro and in situ formulations specifically tailored to ART by adjusting the viscosity of current cements while maintaining high Ca and PO4 ion release, remineralization potential and greater strength than glass ionomer cements; 2. Develop a remineralizing root caries restorative material; 3. Develop a slow-release biodegradable coating for hypersensitive teeth, caries repair, and prevention; 4. Formulate remineralizing orthodontic and crown and bridge cements and study the enamel protection from the orthodontic cement in a clinical trial. Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries.