RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES

树脂基再矿化水泥和复合材料

• 批准号: 7460766
• 负责人: SABINE H DICKENS
• 金额: $ 26.73万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7460766
• 关键词: Adhesions; Adhesive cement; Adhesives; Area; Biocompatible; Calcium Binding; Caries prevention; Cervical; Chemicals; Clinical Research; Clinical Trials; Complex; Country; Dental Cavity Lining; Dental Enamel; Dental Prosthesis; Dental Pulp Capping; Dental caries; Dental crowns; Dentin; Dentin Sensitivity; Development; Devices; Diagnosis; Disease; Drug Formulations; Elderly; Environment; Esthetics; Family; Fiber; Filler; Film; Fluoride Ion; Fluorides; Funding; Glass Ionomer Cements; Glycerol; Goals; Grant; Hypersensitivity; In Situ; In Vitro; Ions; Knowledge; Lead; Learning; Lesion; Light; Localized; Methacrylates; Methods; Minerals; Modeling; Modification; Mouth Diseases; Object Attachment; Oral; Oral cavity; Orthodontic; Orthodontic Brackets; Particle Size; Plant Resins; Preparation; Prevention; Preventive; Property; Prosthesis; Psychological reinforcement; Recurrence; Research; Research Personnel; Residual state; Risk; Root Caries; Saliva; Services; Silicates; Solutions; Structure; Swelling; System; Testing; Therapeutic; Thick; Time; Tissues; Tooth structure; Toxicity Tests; Vibrissae; Viscosity; Week; Work; World Health Organization; base; biomaterial compatibility; calcium phosphate; chemical property; concept; demineralization; design; disorder prevention; glass ionomer; improved; in vivo; inorganic phosphate; microleakage; monomer; novel; novel strategies; physical property; prevent; programs; pyromellitic dianhydride glycerol dimethacrylate adduct; remineralization; remineralizing cement; repaired; research study; restoration; restorative composite; restorative material; restorative treatment; tooth surface

DESCRIPTION: The goals are to develop resin-based remineralizing materials for improved prevention and treatment of caries, one of the most prevalent oral diseases often recurring after restorative treatment and occurring as root caries in the elderly. A more conservative treatment of caries known as atraumatic restorative treatment (ART), to which these materials could be applied, has recently become popular. Here, resin-based bioactive composites containing calcium phosphate (Ca-PO4) fillers for the release of Ca and P04 ions and, where applicable, fibers or whiskers for reinforcement are developed for the remineralization treatment of hypersensitivity and various caries-related diseases, e.g., the prevention of recurrent caries. The composites contain acidic- and other methacrylate resins, Ca-PO4 fillers and, if indicated fluoride additives. The basic composition is closely related to those described in previously funded work, which led to a highly biocompatible cement with excellent results when used as a remineralizing agent for in vitro generated tooth lesions and as a direct pulp-capping agent in vivo. Hypothesis: Existing resin-based bioactive composites and cements can be modified for applications, where remineralizing and caries preventive capabilities are of greatest importance. Specific Aims: 1. Develop and test in vitro and in situ formulations specifically tailored to ART by adjusting the viscosity of current cements while maintaining high Ca and PO4 ion release, remineralization potential and greater strength than glass ionomer cements; 2. Develop a remineralizing root caries restorative material; 3. Develop a slow-release biodegradable coating for hypersensitive teeth, caries repair, and prevention; 4. Formulate remineralizing orthodontic and crown and bridge cements and study the enamel protection from the orthodontic cement in a clinical trial. Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries.

龋齿是最常见的口腔疾病之一，在修复治疗后经常复发，以老年人牙根性龋齿的形式发生，目的是开发树脂基再矿化材料，以改善龋齿的预防和治疗。一种更为保守的龋齿治疗方法被称为非创伤性修复治疗（ART），这些材料可以应用于这种治疗方法，最近变得流行起来。