RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES

树脂基再矿化水泥和复合材料

• 批准号: 7241510
• 负责人: SABINE H DICKENS
• 金额: $ 27.02万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7241510
• 关键词: Adhesions; Adhesive cement; Adhesives; Area; Biocompatible; Calcium Binding; Caries prevention; Cervical; Chemicals; Clinical Research; Clinical Trials; Complex; Country; Dental Cavity Lining; Dental Enamel; Dental Prosthesis; Dental Pulp Capping; Dental caries; Dental crowns; Dentin; Dentin Sensitivity; Development; Devices; Diagnosis; Disease; Drug Formulations; Elderly; Environment; Esthetics; Family; Fiber; Filler; Film; Fluoride Ion; Fluorides; Funding; Glass Ionomer Cements; Glycerol; Goals; Grant; Hypersensitivity; In Situ; In Vitro; Ions; Knowledge; Lead; Learning; Lesion; Light; Localized; Methacrylates; Methods; Minerals; Modeling; Modification; Mouth Diseases; Object Attachment; Oral; Oral cavity; Orthodontic; Orthodontic Brackets; Particle Size; Plant Resins; Preparation; Prevention; Preventive; Property; Prosthesis; Psychological reinforcement; Recurrence; Research; Research Personnel; Residual state; Risk; Root Caries; Saliva; Services; Silicates; Solutions; Structure; Swelling; System; Testing; Therapeutic; Thick; Time; Tissues; Tooth structure; Toxicity Tests; Vibrissae; Viscosity; Week; Work; World Health Organization; base; biomaterial compatibility; calcium phosphate; chemical property; concept; demineralization; design; disorder prevention; glass ionomer; improved; in vivo; inorganic phosphate; microleakage; monomer; novel; novel strategies; physical property; prevent; programs; pyromellitic dianhydride glycerol dimethacrylate adduct; remineralization; remineralizing cement; repaired; research study; restoration; restorative composite; restorative material; restorative treatment; tooth surface

DESCRIPTION: The goals are to develop resin-based remineralizing materials for improved prevention and treatment of caries, one of the most prevalent oral diseases often recurring after restorative treatment and occurring as root caries in the elderly. A more conservative treatment of caries known as atraumatic restorative treatment (ART), to which these materials could be applied, has recently become popular. Here, resin-based bioactive composites containing calcium phosphate (Ca-PO4) fillers for the release of Ca and P04 ions and, where applicable, fibers or whiskers for reinforcement are developed for the remineralization treatment of hypersensitivity and various caries-related diseases, e.g., the prevention of recurrent caries. The composites contain acidic- and other methacrylate resins, Ca-PO4 fillers and, if indicated fluoride additives. The basic composition is closely related to those described in previously funded work, which led to a highly biocompatible cement with excellent results when used as a remineralizing agent for in vitro generated tooth lesions and as a direct pulp-capping agent in vivo. Hypothesis: Existing resin-based bioactive composites and cements can be modified for applications, where remineralizing and caries preventive capabilities are of greatest importance. Specific Aims: 1. Develop and test in vitro and in situ formulations specifically tailored to ART by adjusting the viscosity of current cements while maintaining high Ca and PO4 ion release, remineralization potential and greater strength than glass ionomer cements; 2. Develop a remineralizing root caries restorative material; 3. Develop a slow-release biodegradable coating for hypersensitive teeth, caries repair, and prevention; 4. Formulate remineralizing orthodontic and crown and bridge cements and study the enamel protection from the orthodontic cement in a clinical trial. Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries.

描述：目标是开发以树脂为基础的再矿化材料，以改善对龋病的预防和治疗。龋病是最常见的口腔疾病之一，在修复治疗后经常复发，在老年人中以根面龋齿的形式出现。最近，一种被称为非创伤性修复治疗(ART)的更保守的龋病治疗方法变得流行起来，这些材料可以应用于这种治疗方法。 在这里，含有用于释放Ca和P04离子的磷酸钙(Ca-PO4)填料以及用于增强的纤维或晶须(如果适用)的树脂基生物活性复合材料被开发用于超敏反应和各种与龋齿相关的疾病的再矿化治疗，例如预防龋齿复发。该复合材料含有酸性和其他甲基丙烯酸酯树脂、Ca-PO4填料和氟化物添加剂(如有说明)。基本成分与以前资助的工作中描述的密切相关，这些工作导致了一种高度生物相容性的水泥，当用作体外产生的牙齿病变的再矿化剂和体内直接盖髓剂时，具有良好的结果。假设：现有的基于树脂的生物活性复合材料和粘固剂可以进行改性，以适用于再矿化和防龋性最重要的应用。具体目标：1.开发和测试专门为ART量身定做的体外和原位配方，通过调整现有粘固剂的粘度，同时保持较高的Ca和PO4离子释放、再矿化潜力和比玻璃离子水门汀更高的强度；2.开发再矿化根面龋修复体材料；3.开发用于牙齿过敏、龋齿修复和预防的缓释生物降解涂层；4.配制再矿化正畸和冠桥粘固剂，并在临床试验中研究正畸水泥对釉质的保护作用。这项研究的完成将导致Ca-PO4水泥和复合材料的粘附性得到改善，ART和根面龋病的治疗强度也得到了提高。