Timing: Pharmacology and Conditioning
时机:药理学和调理
基本信息
- 批准号:6931456
- 负责人:
- 金额:$ 14.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-09-25 至 2007-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Adaptive behavior must be timed appropriately. The goal of this research is to understand the cognitive and neural mechanisms that underlie this ability. The specific aim of this project is to study mechanisms whereby the dopamine system affects temporal information processing. In preliminary work, we replicated the well-documented immediate, unconditioned suppression of responding by the dopamine antagonist pimozide. However, we discovered that after several doses of pimozide, a conditioned response may develop to stimuli associated with drug administration. The conditioned response produces a change in temporal information processing. This grant is designed to explore how this conditioned response arises and how it influences information processing. The dopamine system has been implicated in psychiatric disorders such as schizophrenia and, perhaps, depression. By understanding the role of the dopamine system in cognition and by understanding the contributions of conditioning to the effectiveness of drugs, treatments can be developed that are of more rapid onset and greater effectiveness. Additionally, this work will contribute to understanding the operation and treatment of addictions. The rewarding properties of some addictive drugs appear to be mediated by the dopamine reward system. An understanding of how dopamine affects cognition can provide new understanding of drug effects. Furthermore, cues associated with drug-taking are important modulators of drug tolerance, craving and relapse. Consequently, a better understanding of conditioning processes that accompany drug taking can also lead to more effective interventions.
描述(由申请人提供):适应性行为必须在适当的时机进行。这项研究的目标是了解这种能力背后的认知和神经机制。该项目的具体目的是研究多巴胺系统影响时间信息处理的机制。在初步工作中,我们复制了多巴胺拮抗剂匹莫齐特对反应的立即、无条件抑制,这是有据可查的。然而,我们发现在服用数剂匹莫齐特后,可能会对与给药相关的刺激产生条件反应。条件反应会产生时间信息处理的变化。这笔赠款旨在探索这种条件反应是如何产生的以及它如何影响信息处理。多巴胺系统与精神疾病有关,例如精神分裂症,或许还有抑郁症。通过了解多巴胺系统在认知中的作用以及了解调节对药物有效性的贡献,可以开发起效更快、效果更好的治疗方法。此外,这项工作将有助于了解成瘾的运作和治疗。一些成瘾药物的奖励特性似乎是由多巴胺奖励系统介导的。了解多巴胺如何影响认知可以提供对药物作用的新认识。此外,与吸毒相关的线索是药物耐受性、渴望和复发的重要调节因素。因此,更好地了解伴随吸毒的调节过程也可以导致更有效的干预措施。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Peter D. Balsam其他文献
A Search for Preexposure Effects in Autoshaping: Effects of US-Only or Random CS-US Presentations, Intertrial Interval Duration, and Number of Pretraining Trials
- DOI:
10.1007/bf03394708 - 发表时间:
2017-05-31 - 期刊:
- 影响因子:0.800
- 作者:
Peter D. Balsam;C. M. Locurto;Herbert S. Terrace;John Gibbon - 通讯作者:
John Gibbon
DISSECTING MOTIVATION IN ANIMAL MODELS OF DOPAMINE DYSFUNCTION
- DOI:
10.1016/s0920-9964(14)70132-x - 发表时间:
2014-04-01 - 期刊:
- 影响因子:
- 作者:
Eleanor H. Simpson;Ryan D. Ward;Eric R. Kandel;Peter D. Balsam - 通讯作者:
Peter D. Balsam
Effects of reinforcing preselected approximations on the topography of the rat's bar press.
增强预选近似值对大鼠杠铃推举地形的影响。
- DOI:
10.1901/jeab.1991.55-213 - 发表时间:
1991 - 期刊:
- 影响因子:2.7
- 作者:
Patricia D. Stokes;Peter D. Balsam - 通讯作者:
Peter D. Balsam
The locust of control and other plagues
- DOI:
10.1016/s0005-7894(78)80034-3 - 发表时间:
1978-11-01 - 期刊:
- 影响因子:
- 作者:
Peter D. Balsam;Andrew S. Bondy - 通讯作者:
Andrew S. Bondy
Peter D. Balsam的其他文献
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