CANCER EPIDEMIOLOGY IN ADVENTISTS--A LOW RISK GROUP

复临信徒的癌症流行病学——低风险群体

• 批准号: 6915782
• 负责人: GARY E. FRASER
• 金额: $ 256.7万
• 依托单位: LOMA LINDA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6915782
• 关键词: African American; body physical activity; breast neoplasms; calcium; cancer risk; caucasian American; clinical research; colon neoplasms; dietary lipid; flavones; folate; human subject; meat; neoplasm /cancer epidemiology; nutrition aspect of cancer; nutrition related tag; prostate neoplasms; religious group; soybeans; tomato; vegetables

This application describes a planned cohort study of 80,000 white and 45,000 black adult Seventh-day Adventists, enrolled from across the U.S. Questions not easily addressed by other study populations, can be answered. Taking advantage of the unusual dietary habits of Adventists, the special focus of this application is an association between soy intake, calcium intake, and cancers of the breast, prostate and colon. About half of black and white Adventists consume similar quantities of soy to that used in China or Singapore. Adventists also have a wide variance in intake of calcium. The increasing use of soy and calcium supplements by the American population needs further evidential support. Another strength of the proposed research is the proven ability to enroll and follow a large and cooperative cohort of black Adventists. The very high incidence and mortality ascribed to prostate cancer in black men may be associated with their dietary habits. Subjects will be enrolled church by church using a pretested plan whereby institutional media and respected members at individual churches promote the study. Subjects will complete a comprehensive questionnaire which is already developed and pretested. Cancer surveillance during follow-up will be by matching with state tumor registries where possible, matching with the National Death Index, and by obtaining and coding hospitalization records as necessary. Calibration studies in both black and white Adventists will allow bias correction. We believe that it is important to also gather blood, urine and subcutaneous fat from the subjects, and have a largely pretested plan to accomplish this. This will be further tested for feasibility at a location away from Loma Linda during Year 0 1 of the present study. The Adventist population has been cooperative with epidemiologic research for many years and has some unusual strengths as a research population, including the virtual absence of confounding by tobacco and alcohol, the wide range of dietary habits and the widespread use of soy products. They have made important contributions to the understanding of diet and chronic disease in the past. This larger study will provide much greater statistical power, more accurate and documented exposure assessment, and will also include a large cohort of black Adventists.

本申请描述了一项计划中的队列研究，该研究纳入了80，000名白色和45，000名黑人成人基督复临安息日会信徒，这些信徒来自美国各地。可以回答其他研究人群不容易解决的问题。利用基督复临安息日会不寻常的饮食习惯，这个应用程序的特别重点是大豆摄入量，钙摄入量和乳腺癌，前列腺癌和结肠癌之间的关联。大约一半的黑人和白色基督复临安息日会信徒消耗的大豆数量与中国或新加坡的大豆数量相似。基督复临信徒在钙的摄入量方面也有很大的差异。美国人越来越多地使用大豆和钙补充剂需要进一步的证据支持。拟议中的研究的另一个优势是证明有能力招募和跟踪一个大型的黑人基督复临安息日会合作队列。黑人前列腺癌的高发病率和死亡率可能与他们的饮食习惯有关。受试者将被登记教堂教堂使用预先测试的计划，机构媒体和受尊敬的成员在个别教堂促进研究。受试者将完成一份已经制定和预先测试的综合问卷。随访期间的癌症监测将尽可能与国家肿瘤登记处匹配，与国家死亡指数匹配，并在必要时获得住院记录并进行编码。黑人和白色基督复临安息日会的校准研究将允许偏倚校正。我们认为，重要的是还要收集受试者的血液、尿液和皮下脂肪，并有一个经过大量预先测试的计划来完成这一点。在本研究的第0 - 1年期间，将在远离洛马琳达的地点进一步测试其可行性。基督复临信徒群体多年来一直与流行病学研究合作，并作为研究群体具有一些不寻常的优势，包括几乎不受烟草和酒精的干扰，广泛的饮食习惯和广泛使用豆制品。他们在过去对饮食和慢性病的理解做出了重要贡献。这项规模更大的研究将提供更大的统计功效，更准确和记录的暴露评估，还将包括一个大型黑人基督复临安息日会队列。