Cancer Center Microarray Bioinformatics Facility

描述(由申请人提供)： 这项提案的总体目标是建立DNA微阵列和 霍林斯癌症中心的生物信息学资源设施 南卡罗来纳大学。计划中的NCI资助的资源设施将 以最近的机构投资为基础，创建全面的 基础设施包括教职员工、支持人员、最先进的 仪器和高级计算/统计分析资源 需要促进使用DNA微阵列分析来识别图谱 在特定的癌症相关过程中表达的基因。的主要目标 建议包括为调查人员提供专家咨询和 在DNA微阵列过程的所有关键阶段提供协助 分析包括初步的实验计划阶段，分子生物学 阶段，一直到数据分析阶段。后者将涉及 实施商业软件应用程序以及一些 支持生物信息学专家开发的先进计算机算法 穿过核心。最后，资源工具将创建一个 互联网上收集的基因表达谱信息数据库 由肝细胞癌研究人员将这些数据提供给科学界 逍遥法外。

DESCRIPTION (provided by applicant): The overall goal of this proposal is to establish a DNA Microarray and Bioinformatics Resource Facility at the Hollings Cancer Center (HCC), Medical University of South Carolina. The planned NCI-funded resource facility will build upon recent institutional investments and create a comprehensive infrastructure comprised of faculty, support staff, state-of-the-art instrumentation and advanced computational/statistical analysis resources required to facilitate the use of DNA microarray analysis to identify profiles of genes expressed in specific cancer-related processes. Major goals of the proposal include providing investigators with expert consultation and assistance through all critical phases of the process of DNA microarray analysis including the initial experimental planning phase, molecular biology phase and through to the data analysis phase. The latter will involve implementation of both commercial software applications as well as a number of advanced computer algorithms developed by bioinformatics specialists supported through the core. Finally, the resource facility will create an internet-accessible database of gene expression profile information collected by HCC investigators to make this data available to the scientific community at large.