PROTEOGENOMICS

蛋白质组学

• 批准号: 8167790
• 负责人: WILLIAM SCOTT ARGRAVES
• 金额: $ 23.4万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167790
• 关键词: Address; Arts; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Consultations; Funding; Gene Expression Profiling; Genomics; Grant; Institution; Lasers; Methods; Oral health; Protein Biochemistry; Proteins; Proteomics; RNA; Research; Research Personnel; Resources; Services; Single Nucleotide Polymorphism; Source; Surface; Technology; Tissues; Training; United States National Institutes of Health; base; chromatin immunoprecipitation; instrumentation; programs; protein function; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the Proteogenomics (Core C) is to provide project investigators with a resource for expert consultation, technical training, and state-of-the-art instrumentation to enable advancement of their research efforts through the application of high throughput genomic analysis, qPCR and protein based ('proteomic') approaches. The genomic component permits investigators to use several microarray-based technologies including comprehensive gene expression profiling, single nucleotide polymorphism, and chromatin immunoprecipitation-chip methods; the core also provides advanced computational/statistical analysis tools and training for these technologies. We have also recently expanded our genomics services by adding RNA multiplex analysis and laser capture microdissected tissue. The proteomics component provides investigators with technical assistance and instrumentation resources to use conventional and cutting edge protein biochemistry-based technologies including multiplex bead array and surface plasmon technology to address questions of protein function. During the last year COBRE Core C continued to provide genomics and proteomics services to both past and present COBRE trainees (see attached Table 1), including trainees funded by the Lipidomics COBRE program (RR107677, L. Obeid, PI) the Oral Health COBRE Program (RR017696) and the SC INBRE program (RR16461, L. Pirise-Creek, PI).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 蛋白质组学（核心C）的目的是为项目研究人员提供专家咨询，技术培训和最先进的仪器的资源，以通过应用高通量基因组分析，QPCR和基于蛋白质（'蛋白质组学'）方法来实现其研究工作。基因组成分允许研究人员使用几种基于微阵列的技术，包括综合基因表达分析，单核苷酸多态性和染色质免疫沉淀-CHIP方法；核心还为这些技术提供了高级计算/统计分析工具和培训。最近，我们还通过添加RNA多重分析和激光捕获微解剖组织来扩展基因组学服务。蛋白质组学组件为研究人员提供了技术援助和仪器资源，以使用基于传统和最先进的蛋白质生物化学技术，包括多重珠阵列和表面等离子体技术来解决蛋白质功能的问题。在过去的一年中，Cobre Core C继续为过去和现在的Cobre受训者提供基因组学和蛋白质组学服务（请参阅附件1），包括由脂质组学Cobre计划（RR107677，L。Obeid，L。Obeid，PI，PI）资助的受训者（PI），口服健康Cobre Program（RR017696）和SC INBRE Program（RR017696）（RR166161616），RR16，RR16，RRR16，RRR161，RR 161，RR 161，RR。 pi）。