The UCSD/San Diego Resuscitation Research Center

加州大学圣地亚哥分校/圣地亚哥复苏研究中心

• 批准号: 6941224
• 负责人: David B. Hoyt
• 金额: $ 47.09万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941224
• 关键词: body fluid balance therapy; cardiopulmonary resuscitation; clinical research; clinical trials; combination therapy; cooperative study; electric countershock heart resuscitation; emergency health services; health services research tag; heart arrest; hemorrhagic shock; human subject; human therapy evaluation; hypertonia; patient oriented research; saline; training; trauma; ventricular fibrillation

DESCRIPTION (provided by applicant): The UCSD/San Diego Resuscitation Research Center (USRRC) is a regional research network which performs resuscitation research in cardiac arrest and trauma. San Diego County is bordered by a military preserve (Camp Pendleton) to the North, Mexico to the South, the dessert to the East and the Pacific Ocean to the West. This clinical resuscitation research network integrates pre-hospital care, receiving trauma centers, and receiving hospitals for cardiac arrest into an organized network to allow population based pre-hospital research. The USRRC is designed with critical EMS and trauma center leadership, resources to train paramedics in protocol implementation, and a data system to track patient entry and patient follow up. The data system can be modified to accommodate research questions and additional data acquisition as protocols and research questions change. A Clinical Research Skills Development Core is proposed and is supplemented by an existing Clinical Research Training Program at UCSD. Together these will provide a rich opportunity to enhance training in prehospital clinical research for postgraduate MD fellows and young faculty in surgery, emergency medicine or cardiology. The center proposes a trauma trial that will evaluate hypertonic saline/dextran (HDS) as a prehospital resuscitation fluid for hemorrhagic shock in patients following injury. It is expected that this will alter the incidence of multiple organ failure and the mortality associated with multiple organ failure (MOF) by modulating the over-stimulated inflammatory system which follows hemorrhagic shock in injured patients. MOF remains the late cause of death following trauma. A second trial for patients following cardiac arrest evaluates the importance of cardiopulmonary resuscitation (CPR) in patients who are found down for more than 4 minutes following ventricular fibrillation. It is thought that CPR prior to defibrillation may improve outcomes for patients following cardiac arrest with down times greater than four minutes. There are adequate patients in San Diego County to complete these trials in approximately three years.

描述(由申请人提供)： 加州大学圣地亚哥分校复苏研究中心(USRRC)是一个地区性研究网络，对心脏骤停和创伤进行复苏研究。圣地亚哥县北部是军事保护区(彭德尔顿军营)，南部是墨西哥，东部是甜点，西部是太平洋。这个临床复苏研究网络将院前护理、接收创伤中心和接收心脏骤停的医院整合到一个有组织的网络中，以允许进行基于人群的院前研究。USRRC设计了关键的EMS和创伤中心领导层，培训护理人员执行方案的资源，以及跟踪患者进入和患者随访的数据系统。随着协议和研究问题的变化，可以修改数据系统以适应研究问题和额外的数据获取。提出了临床研究技能发展核心，并辅之以加州大学圣迭戈分校现有的临床研究培训计划。这些都将为外科、急救医学或心脏病学的研究生MD研究员和年轻教员提供一个丰富的机会来加强院前临床研究方面的培训。 该中心提出了一项创伤试验，将评估高渗盐水/葡聚糖(HDS)作为院前复苏液体治疗创伤后失血性休克患者的效果。预计这将通过调节创伤患者失血性休克后过度刺激的炎症系统来改变多器官衰竭的发生率和与多器官衰竭(MOF)相关的死亡率。MOF仍然是创伤后的晚期死亡原因。针对心脏骤停患者的第二项试验评估了心肺复苏(CPR)在室颤后被发现昏迷超过4分钟的患者中的重要性。据认为，在除颤之前进行CPR可能会改善心脏骤停后停搏时间超过4分钟的患者的预后。圣地亚哥县有足够的患者在大约三年内完成这些试验。