Role of Genotype and Maternal Smoking on Brain MAO A

基因型和母亲吸烟对大脑 MAO A 的作用

• 批准号: 6959844
• 负责人: JOANNA S FOWLER
• 金额: $ 13.71万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-05 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6959844
• 关键词: MAO inhibitors; Macaca; amine oxidase (flavin); behavioral /social science research tag; behavioral genetics; bioimaging /biomedical imaging; clinical research; compulsive behavior; developmental genetics; early experience; embryo /fetus toxicology; genotype; human subject; isozymes; molecular /cellular imaging; neurochemistry; neurogenetics; neuropharmacology; neurophysiology; neuropsychological tests; neuropsychology; personality; pharmacogenetics; positron emission tomography; tobacco; tobacco abuse

DESCRIPTION (provided by applicant): This is a new application for K05 Senior Scientist Award. The applicant, Dr. Joanna S. Fowler, Director of the Center for Translational Neuroimaging is an organic chemist with a distinguished record of accomplishments in the development and applications of radiotracers for the neurosciences including the development of 18FDG, the development of the first radiotracers for monoamine oxidase (MAO) (and the discovery that smokers have reduced brain MAO) and the application of PET in the study of drug addiction. She is also a sought after lecturer in bringing the power of science and brain imaging to the problem of drug addiction. She is currently mentoring several junior scientists in addition to her administrative duties as Center Director. If funded, this K award will provide 60% salary support, which will provide at least 75% protected time to focus intensely on her new interests in understanding the links between genes, the environment and behavior, and on mentoring. In support of this application, the Department has agreed to use the funds released from the Program to hire an administrator to assume the administrative duties that are now performed by Dr. Fowler. There are 2 major activities: (1) Research (60%): to investigate the role of monoamine oxidase (MAO) genotype and maternal smoking on brain MAO, brain function and behavior and (2) Mentoring (15%): to mentor junior clinical scientists, graduate students and post-doctoral fellows in trans-disciplinary research related to substance abuse. The research in this application takes advantage of outstanding collaborators at Brookhaven, SUNY Stony Brook and SUNY Downstate and Kings College (London, UK) and is funded by our major Department of Energy grant which was recently peer reviewed and renewed for 5 years. These goals build on the urgent need to understand the role of gene-brain-behavior relationships and developmental stressors in substance abuse and the need to train and inspire scientists across disciplines to respond to the major public health problems created by drug addiction.

描述（由申请人提供）： 这是K 05高级科学家奖的新申请。申请人Joanna S. Fowler是一位有机化学家，在神经科学放射性示踪剂的开发和应用方面取得了杰出的成就，包括18 FDG的开发，单胺氧化酶（MAO）的第一个放射性示踪剂的开发（以及发现吸烟者减少了大脑MAO）和PET在药物成瘾研究中的应用。她也是一位受欢迎的讲师，将科学和大脑成像的力量带到吸毒成瘾问题上。她目前正在指导几个年轻的科学家除了她的行政职责作为中心主任。如果获得资助，这个K奖将提供60%的工资支持，这将提供至少75%的保护时间，集中在她的新兴趣，了解基因，环境和行为之间的联系，并在指导。为了支持这一申请，该部已同意使用该方案释放的资金雇用一名管理员承担目前由福勒博士履行的行政职责。有两个主要活动：（1）研究（60%）：调查单胺氧化酶（MAO）基因型和母亲吸烟对大脑MAO，大脑功能和行为的作用;（2）指导（15%）：指导初级临床科学家，研究生和博士后研究员进行与药物滥用有关的跨学科研究。该应用程序中的研究利用了Brookhaven，SUNY斯托尼布鲁克和SUNY Downstate和Kings College（伦敦，英国）的杰出合作者，并由我们的主要能源部资助，最近经过同行评审并续签了5年。这些目标建立在迫切需要了解药物滥用中基因-大脑-行为关系和发育压力源的作用以及需要培训和激励跨学科科学家应对药物成瘾造成的重大公共卫生问题的基础上。