Role of Genotype and Maternal Smoking on Brain MAO A

基因型和母亲吸烟对大脑 MAO A 的作用

• 批准号: 7634536
• 负责人: JOANNA S FOWLER
• 金额: $ 13.71万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-05 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7634536
• 关键词: AIDS/HIV problem; Administrator; Adult; Aggressive behavior; Anger; Behavior; Brain; Brain imaging; Child; Clinical; Clorgyline; Cognitive; Department of Energy; Development; Discipline; Disease; Dopamine; Drug Addiction; Drug abuse; Emotions; Environment; Enzymes; Funding; Genes; Genetic Polymorphism; Genotype; Goals; Grant; Human; Image; Individual; Investigation; K-Series Research Career Programs; Knowledge; Life; Link; London; Measures; Mental disorders; Mentors; Methaqualone; Modeling; Monoamine Oxidase; Monoamine Oxidase A; Neurosciences; Neurotransmitters; Norepinephrine; Peer Review; Personality; Pharmaceutical Preparations; Phenotype; Play; Positron-Emission Tomography; Postdoctoral Fellow; Pregnancy; Public Health; Questionnaires; Reporting; Research; Rest; Risk-Taking; Rodent; Role; Scanning; Science; Scientist; Senior Scientist Award; Serotonin; Sex Behavior; Smoke; Smoker; Smoking; Substance abuse problem; Testing; Time; Training; Violence; Wages; addiction; base; behavior test; brain behavior; college; fetal; fetal tobacco exposure; glucose metabolism; graduate student; human subject; interest; lecturer; male; maternal cigarette smoking; neurochemistry; neuroimaging; neuropsychological; nonhuman primate; offspring; programs; promoter; radiotracer; stressor

DESCRIPTION (provided by applicant): This is a new application for K05 Senior Scientist Award. The applicant, Dr. Joanna S. Fowler, Director of the Center for Translational Neuroimaging is an organic chemist with a distinguished record of accomplishments in the development and applications of radiotracers for the neurosciences including the development of 18FDG, the development of the first radiotracers for monoamine oxidase (MAO) (and the discovery that smokers have reduced brain MAO) and the application of PET in the study of drug addiction. She is also a sought after lecturer in bringing the power of science and brain imaging to the problem of drug addiction. She is currently mentoring several junior scientists in addition to her administrative duties as Center Director. If funded, this K award will provide 60% salary support, which will provide at least 75% protected time to focus intensely on her new interests in understanding the links between genes, the environment and behavior, and on mentoring. In support of this application, the Department has agreed to use the funds released from the Program to hire an administrator to assume the administrative duties that are now performed by Dr. Fowler. There are 2 major activities: (1) Research (60%): to investigate the role of monoamine oxidase (MAO) genotype and maternal smoking on brain MAO, brain function and behavior and (2) Mentoring (15%): to mentor junior clinical scientists, graduate students and post-doctoral fellows in trans-disciplinary research related to substance abuse. The research in this application takes advantage of outstanding collaborators at Brookhaven, SUNY Stony Brook and SUNY Downstate and Kings College (London, UK) and is funded by our major Department of Energy grant which was recently peer reviewed and renewed for 5 years. These goals build on the urgent need to understand the role of gene-brain-behavior relationships and developmental stressors in substance abuse and the need to train and inspire scientists across disciplines to respond to the major public health problems created by drug addiction.

描述（由申请人提供）：

项目成果

Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity.

• DOI: 10.1371/journal.pone.0011067
• 发表时间: 2010-06-10
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Shumay E;Fowler JS;Volkow ND
• 通讯作者: Volkow ND

Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain.

• DOI: 10.1038/npp.2014.214
• 发表时间: 2015-02
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Identification and characterization of putative methylation targets in the MAOA locus using bioinformatic approaches.

• DOI: 10.4161/epi.5.4.11719
• 发表时间: 2010-05-16
• 期刊: Epigenetics
• 影响因子: 3.7
• 作者: Shumay E;Fowler JS
• 通讯作者: Fowler JS

Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon.

JNJ-39220675 阻断大脑组胺 H3 受体：在麻醉狒狒中使用 [11C]GSK189254 进行临床前 PET 研究。

• DOI: 10.1007/s00213-012-2733-x
• 发表时间: 2012
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Logan,Jean;Carruthers,NicholasI;Letavic,MichaelA;Sands,Steven;Jiang,Xiaohui;Shea,Colleen;Muench,Lisa;Xu,Youwen;Carter,Pauline;King,Payton;Fowler,JoannaS
• 通讯作者: Fowler,JoannaS

Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons.

• DOI: 10.1016/j.biopsych.2010.01.004
• 发表时间: 2010-04-15
• 期刊: BIOLOGICAL PSYCHIATRY
• 影响因子: 10.6
• 作者: Biegon, Anat;Kim, Sung-Won;Logan, Jean;Hooker, Jacob M.;Muench, Lisa;Fowler, Joanna S.
• 通讯作者: Fowler, Joanna S.