PET STUDIES OF THE PHARMACOKINETICS OF D-METHAMPHETAMINE IN THE HUMAN BODY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 有许多生物和药理学因素可能解释了甲基苯丙胺的高成瘾潜力和毒性。一个可能的候选者是它在大脑和其他器官中的药代动力学。然而，甲基苯丙胺在人脑和其他器官中的药代动力学尚不清楚。在这里，我们提出了一项系统的研究，用PET和碳-11标记的d-甲基苯丙胺在一组正常健康的非药物滥用志愿者的脑和外周器官中摄取和动力学d-甲基苯丙胺(活性异构体)。我们还将把这项大脑研究与使用[11C]可卡因的多巴胺转运体(DAT)可用性的测量方法配对，以测量相同个体的DAT水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are a number of biological and pharmacological factors, which may account for methamphetamine's high addictive potential and for its toxicity. One likely candidate is its pharmacokinetics in the brain and other organs. However, methamphetamine's pharmacokinetics in the human brain and in other organs are not known. Here we propose a systematic investigation of the uptake and kinetics of d-methamphetamine (the active isomer) in the brain and in peripheral organs with PET and carbon-11 labeled d-methamphetamine in a group of normal healthy non-drug abusing volunteers. We will also pair the brain study with a measure of dopamine transporter (DAT) availability using [11C]cocaine to measure DAT levels in the same individuals.