PET STUDIES OF THE PHARMACOKINETICS OF D-METHAMPHETAMINE IN THE HUMAN BODY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 有一些生物学和药理学因素可能是甲基苯丙胺高度成瘾性及其毒性的原因。 一个可能的候选者是它在大脑和其他器官中的药代动力学。 然而，甲基苯丙胺在人脑和其他器官中的药代动力学尚不清楚。 在这里，我们提出了一个系统的调查的摄取和动力学的d-甲基苯丙胺（活性异构体）在大脑和外周器官与PET和碳-11标记的d-甲基苯丙胺在一组正常健康的非药物滥用志愿者。 我们还将把大脑研究与使用[11 C]可卡因测量多巴胺转运蛋白（DAT）可用性的措施配对，以测量同一个体的DAT水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are a number of biological and pharmacological factors, which may account for methamphetamine's high addictive potential and for its toxicity. One likely candidate is its pharmacokinetics in the brain and other organs. However, methamphetamine's pharmacokinetics in the human brain and in other organs are not known. Here we propose a systematic investigation of the uptake and kinetics of d-methamphetamine (the active isomer) in the brain and in peripheral organs with PET and carbon-11 labeled d-methamphetamine in a group of normal healthy non-drug abusing volunteers. We will also pair the brain study with a measure of dopamine transporter (DAT) availability using [11C]cocaine to measure DAT levels in the same individuals.