MONOAMINE OXIDASE (MAO) GENETICS AND BRAIN FUNCTION

单胺氧化酶 (MAO) 遗传学和脑功能

• 批准号: 7607907
• 负责人: JOANNA S FOWLER
• 金额: $ 0.1万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-23 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607907
• 关键词: Behavior; Brain; Computer Retrieval of Information on Scientific Projects Database; Dopamine; Enzymes; Funding; Genes; Genetic; Genetic Polymorphism; Genotype; Grant; Individual; Institution; Monoamine Oxidase; Monoamine Oxidase A; Neurotransmitters; Norepinephrine; Population; Research; Research Personnel; Resources; Serotonin; Source; United States National Institutes of Health; Variant; male; mood regulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Monoamine oxidase (MAO) is an enzyme that breaks down neurotransmitters such as dopamine, serotonin and norepinephrine, which are involved in the regulation of mood and behavior. There is common normal variation (also called polymorphism) in the MAO gene, referred to as the "high" or "low" MAO A genotype. High and low MAO A genotypes occur in a ratio of 6:4 in the normal male population. However, we do not know if high MAO A genotype individuals also have high levels of MAO A in their brains, nor do we know if low MAO A genotype individuals have low MAO A in their brains. This study will determine whether individuals who have the high or low MAO A genotype also have high or low brain MAO A. This is is important because it is a first step in understanding the relationship of genes to behavior.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 单胺氧化酶 (MAO) 是一种分解多巴胺、血清素和去甲肾上腺素等神经递质的酶，这些神经递质参与情绪和行为的调节。 MAO 基因存在常见的正常变异（也称为多态性），称为“高”或“低”MAO A 基因型。 在正常男性人群中，高 MAO A 基因型和低 MAO A 基因型的比例为 6:4。然而，我们不知道高 MAO A 基因型个体的大脑中是否也具有高水平的 MAO A，也不知道低 MAO A 基因型个体的大脑中是否也具有低 MAO A。 这项研究将确定具有高或低 MAO A 基因型的个体是否也具有高或低大脑 MAO A。这很重要，因为这是了解基因与行为关系的第一步。