EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

校外研究设施建设

• 批准号: 6834738
• 负责人: RIGHARD D KRUGMAN
• 金额: $ 292.12万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-22 至 2006-09-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834738
• 关键词: EXTRAMURAL; RESEARCH; FACILITIES; CONSTRUCTION

DESCRIPTION (provided by applicant): This application requests $3,221,187 of matching funds to finish 31,000 asf/45,400 gsf on the second and third floors of the Davis building. The finished space will house newly created Autoimmunity and Immunotherapeutics Center that will closely collaborate with what is probably the largest Type 1 diabetes center in the country devoted to both clinical care and Type 1 (the autoimmune form) diabetes research occupying the remaining 63,100 gross square feet of the building. A revolution in our understanding of both autoimmune diseases and immunotherapeutics and a faculty at the forefront of both of these fields, has led to this proposal. Type 1 diabetes is a chronic autoimmune disorder and a common paradigm of disease prediction can be applied to both organ specific and non-organ specific autoimmunity, and such autoimmune disorders are probably more similar than different, differing primarily in the autoantigens that are the target of autoimmunity. Thus, there is a tremendous benefit in sharing ideas, equipment, reagents, conferences and pioneering prospective studies of autoimmunity. The shelled space when finished will house faculty and their laboratories devoted to basic and clinical research with research programs in type 1 diabetes, transplantation immunobiology, clinical immunology and rheumatology. Initial faculty will have appointments in pediatric and adult endocrinology, genetics, preventive medicine, cell and structural biology, immunology, rheumatology, clinical immunology, autoimmune pulmonary and gastroenterology disorders and will be a resource not only for the campus but also for national/international scientists. The nidus of the program faculty has already developed many close ties despite current geographic dispersion. They have successfully competed in the past four years for a National Institutes of Health Diabetes Endocrine Research Center, an Autoimmunity Center of Excellence, an Autoimmunity Prevention Center, an Islet Cell Resource Center and a Beta-biology consortium Center. There is an opportunity to create interdisciplinary programs where therapy of disorders such as type 1 diabetes and celiac disease are approached not as an endocrine or gastrointestinal disorder but at their immunologic root. In addition disorders such as rheumatoid arthritis will benefit from the disease prediction paradigms and assay technology already developed in studies of type 1 diabetes. Finally, our faculty is dedicated to training of the next generation of basic and clinical researchers and these efforts also are critically dependent upon shared facilities. The University of Colorado Board of Regents has approved the 4 story plus partial basement 108,500 gsf Barbara Davis Center at Fitzsimons as an integral component of the University of Colorado School of Medicine.

描述（由申请人提供）： 这项申请要求3,221,187美元的配套资金，以完成戴维斯大楼二楼和三楼的31,000 asf/45,400 gsf。完成的空间将容纳新创建的自身免疫和免疫治疗中心，该中心将与可能是该国最大的1型糖尿病中心密切合作，致力于临床护理和1型（自身免疫形式）糖尿病研究，占据建筑物的剩余63，100平方英尺。 我们对自身免疫性疾病和免疫治疗的理解以及这两个领域最前沿的教师的革命导致了这一提议。1型糖尿病是一种慢性自身免疫性疾病，并且疾病预测的常见范例可以应用于器官特异性和非器官特异性自身免疫性两者，并且这样的自身免疫性疾病可能比不同的更相似，主要在作为自身免疫性靶的自身抗原方面不同。因此，在分享想法，设备，试剂，会议和开创性的自身免疫性前瞻性研究方面有巨大的好处。建成后，这个带壳的空间将容纳致力于基础和临床研究的教师及其实验室，研究项目包括1型糖尿病、移植免疫生物学、临床免疫学和风湿病学。最初的教师将在儿科和成人内分泌学，遗传学，预防医学，细胞和结构生物学，免疫学，风湿病学，临床免疫学，自身免疫性肺和胃肠疾病的任命，将不仅是校园的资源，也为国家/国际科学家。尽管目前地理位置分散，但该计划教师的nidus已经建立了许多密切的联系。在过去的四年里，他们成功地竞争了国立卫生研究院糖尿病内分泌研究中心，自身免疫卓越中心，自身免疫预防中心，胰岛细胞资源中心和β生物学联盟中心。有机会创建跨学科项目，其中1型糖尿病和乳糜泻等疾病的治疗不是作为内分泌或胃肠道疾病，而是从免疫学的角度进行的。此外，类风湿性关节炎等疾病将受益于1型糖尿病研究中已经开发的疾病预测模式和测定技术。最后，我们的教师致力于培养下一代基础和临床研究人员，这些努力也严重依赖于共享设施。科罗拉多大学董事会已批准4层加部分地下室108,500 gsf芭芭拉戴维斯中心在菲茨西蒙斯作为一个不可分割的组成部分，科罗拉多大学医学院。