A Novel Load Sensing Tibial Prosthesis Design

一种新型负载传感胫骨假体设计

• 批准号: 6982892
• 负责人: Darryl D. D'Lima
• 金额: $ 23.24万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6982892
• 关键词: arthroplasty; biomaterial compatibility; biomaterial development /preparation; biomechanics; clinical research; human subject; knee; model design /development; patient oriented research; physical model; skeletal prosthesis; telemetry; tibia

DESCRIPTION (provided by applicant): Accurate in vivo measurement of tibiofemoral force is important in total knee arthroplasty as this determines polyethylene stresses and cold flow, stress distribution in the implant, and stress transfer to the underlying implant bone interface. Theoretic estimates of tibiofemoral forces have varied widely depending on the mathematical models used. The six-degree of freedom of motion, complex articular surface topography, changing joint contact position, intra- and extra-articular ligaments, number of muscles crossing the knee joint and the presence of the patellofemoral joint contribute to the difficulty in developing reliable models of the knee. The purpose of this developmental research grant is to design, manufacture and test an instrumented total knee replacement tibial prosthesis that accurately measures all six components of tibial forces in vivo after total knee arthroplasty. These will be accomplished under the following Specific Aims. Aim 1) Design and develop a prototype total knee arthroplasty tibial component instrumented with strain gauges and a telemetry system. Aim 2) In vitro cadaver testing to demonstrate accuracy, feasibility, and integrity of telemetry link. Aim 3) Trial intraoperative implantation. This device can be used to validate existing models of the knee that estimate these forces or to develop more accurate models. In conjunction with kinematic data, accurate tibiofemoral force data may be used to design more effective knee testing rigs and wear simulators. Additional uses are intraoperative measurement of forces to determine soft tissue balancing, evaluation of the effects of rehabilitation, external bracing, and athletic activities, and activities of daily living.

描述(申请人提供)：准确的体内测量胫股力量在全膝关节置换术中非常重要，因为这决定了聚乙烯应力和冷流、植入物中的应力分布以及应力传递到底层植入物骨界面处。根据所使用的数学模型，胫股力量的理论估计有很大的不同。六自由度的运动、复杂的关节表面形态、不断变化的关节接触位置、关节内外韧带、横跨膝关节的肌肉数量以及髌股关节的存在，都增加了建立可靠的膝关节模型的难度。这项开发研究拨款的目的是设计、制造和测试一种仪器化的全膝关节置换胫骨假体，它可以准确地测量全膝关节置换术后体内胫骨力的所有六个分量。 这些将在以下具体目标下实现。目的1)利用应变片和遥测系统设计研制全膝关节置换术胫骨假体样机。目的2)体外身体实验，以验证遥测链路的准确性、可行性和完整性。目的3)试探术中植入。这个设备可以用来验证现有的膝盖模型，这些模型可以估计这些力，或者开发更准确的模型。结合运动学数据，准确的胫股力量数据可用于设计更有效的膝关节试验台和磨损模拟器。其他用途是术中测量力量以确定软组织平衡，评估康复、外部支撑和运动活动的效果，以及日常生活活动。