A Novel Load Sensing Tibial Prosthesis Design

一种新型负载传感胫骨假体设计

• 批准号: 7140192
• 负责人: Darryl D. D'Lima
• 金额: $ 22.69万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7140192
• 关键词: arthroplasty; biomaterial compatibility; biomaterial development /preparation; biomechanics; clinical research; human subject; knee; model design /development; patient oriented research; physical model; skeletal prosthesis; telemetry; tibia

DESCRIPTION (provided by applicant): Accurate in vivo measurement of tibiofemoral force is important in total knee arthroplasty as this determines polyethylene stresses and cold flow, stress distribution in the implant, and stress transfer to the underlying implant bone interface. Theoretic estimates of tibiofemoral forces have varied widely depending on the mathematical models used. The six-degree of freedom of motion, complex articular surface topography, changing joint contact position, intra- and extra-articular ligaments, number of muscles crossing the knee joint and the presence of the patellofemoral joint contribute to the difficulty in developing reliable models of the knee. The purpose of this developmental research grant is to design, manufacture and test an instrumented total knee replacement tibial prosthesis that accurately measures all six components of tibial forces in vivo after total knee arthroplasty. These will be accomplished under the following Specific Aims. Aim 1) Design and develop a prototype total knee arthroplasty tibial component instrumented with strain gauges and a telemetry system. Aim 2) In vitro cadaver testing to demonstrate accuracy, feasibility, and integrity of telemetry link. Aim 3) Trial intraoperative implantation. This device can be used to validate existing models of the knee that estimate these forces or to develop more accurate models. In conjunction with kinematic data, accurate tibiofemoral force data may be used to design more effective knee testing rigs and wear simulators. Additional uses are intraoperative measurement of forces to determine soft tissue balancing, evaluation of the effects of rehabilitation, external bracing, and athletic activities, and activities of daily living.

描述（由申请人提供）：胫股力的准确体内测量在全膝关节置换术中非常重要，因为这决定了聚乙烯应力和冷流、植入物中的应力分布以及应力转移到下方植入物骨界面。胫股力的理论估计值根据所用的数学模型而变化很大。六个自由度的运动，复杂的关节表面地形，关节接触位置的变化，关节内和关节外韧带，肌肉的数量跨越膝关节和髌股关节的存在有助于在开发可靠的模型的膝关节的困难。该发展研究基金的目的是设计、制造和测试一种内固定全膝关节置换胫骨假体，该假体可准确测量全膝关节置换术后体内胫骨力的所有六个分量。 这些将在以下具体目标下实现。目的1）设计和开发一个原型全膝关节置换术胫骨部件仪器与应变计和遥测系统。目的2）体外尸体测试，以证明遥测链路的准确性、可行性和完整性。目的3）试验术中植入。该设备可用于验证估计这些力的现有膝关节模型或开发更准确的模型。结合运动学数据，准确的胫股力数据可用于设计更有效的膝关节测试装置和磨损模拟器。其他用途是术中测量力以确定软组织平衡，评估康复效果，外部支撑和体育活动以及日常生活活动。

项目成果

Changes in in vivo knee loading with a variable-stiffness intervention shoe correlate with changes in the knee adduction moment.

• DOI: 10.1002/jor.21183
• 发表时间: 2010-12
• 期刊: JOURNAL OF ORTHOPAEDIC RESEARCH
• 影响因子: 2.8
• 作者: Erhart, Jennifer C.;Dyrby, Chris O.;D'Lima, Darryl D.;Colwell, Clifford W.;Andriacchi, Thomas P.
• 通讯作者: Andriacchi, Thomas P.

An ABJS Best Paper: Dynamic intraoperative ligament balancing for total knee arthroplasty.

ABJS 最佳论文：全膝关节置换术术中动态韧带平衡。

• 发表时间: 2007
• 期刊: Clinical orthopaedics and related research
• 影响因子: 4.2
• 作者: D'Lima,DarrylD;Patil,Shantanu;Steklov,Nikolai;ColwellJr,CliffordW
• 通讯作者: ColwellJr,CliffordW