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A Wireless Neural Microstimulator

无线神经微刺激器

基本信息

批准号：
6868183
负责人：
BRUCE C. TOWE
金额：
$ 18.4万
依托单位：
ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-03-15 至 2007-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6868183
关键词：
bioengineering /biomedical engineering biomedical equipment development brain electrical activity brain electronic stimulator electromyography implant laboratory rat microprocessor /microchip miniature biomedical equipment neuromuscular stimulator portable biomedical equipment radio controlled electronic stimulator ultrasound

项目摘要

DESCRIPTION (provided by applicant): A long sought goal in the development of neuroprosthetics and also in certain medical therapeutics is the wireless stimulation of specific areas of the brain and CNS. We explore an innovative approach to solving this problem that utilizes implanted piezoelectric microchips that convert applied ultrasound to electrical energy sufficient to stimulate excitable tissue. Pilot experiments show that 0.5 ms pulses of 1 MHz ultrasound will remotely activate millimeter-order sized chips of PZT piezoceramic implanted near the frog sciatic nerve and produce a muscle contractile response. This observation suggests a new minimally invasive approach to electrical stimulation of both the peripheral and central nervous system. The microchips are diced from bulk ceramics and sufficiently small in some applications to be introduced into tissue by way of a syringe needle. Experiments suggest the potential to activate the chips at many centimeter depths by a handheld device producing average ultrasound power levels comparable to that used in diagnostic imaging. We propose to investigate the potential for CNS application by employing a rat model. We will evaluate various chip designs, characterize their performance in mock tissue phantoms, and then test their ability to activate rat CNS motor control centers. We envision such an approach may be the basis for development of new neural technologies and has a number of potential applications such as in activation of neural pathways in the brain, functional electrical stimulation, neural control, pain relief, and spinal stimulation.

描述（由申请人提供）：在神经修复术的开发中以及在某些医学治疗中，长期寻求的目标是对大脑和CNS的特定区域进行无线刺激。我们探索一种创新的方法来解决这个问题，利用植入的压电微芯片，将应用的超声波转换为电能足以刺激兴奋组织。初步实验表明，0.5毫秒脉冲的1 MHz的超声将远程激活植入附近的青蛙坐骨神经的PZT压电陶瓷的毫米级大小的芯片，并产生肌肉收缩反应。这一观察结果提出了一种新的微创方法来电刺激外周和中枢神经系统。微芯片由块状陶瓷切割而成，并且在某些应用中足够小以通过注射器针头引入组织中。实验表明，通过手持设备在许多厘米的深度激活芯片，产生的平均超声功率水平与诊断成像中使用的相当。我们建议采用大鼠模型研究CNS应用的潜力。我们将评估各种芯片设计，在模拟组织模型中表征其性能，然后测试其激活大鼠CNS运动控制中心的能力。我们设想这种方法可能是开发新的神经技术的基础，并具有许多潜在的应用，如激活大脑中的神经通路，功能性电刺激，神经控制，疼痛缓解和脊髓刺激。