A Miniature Wireless Neuroelectrode

微型无线神经电极

• 批准号: 7475292
• 负责人: BRUCE C. TOWE
• 金额: $ 19.05万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7475292
• 关键词: Acute; Animals; Arts; Back; Bone Tissue; Brain; Cavia; Characteristics; Clinical; Communication; Communication Aids for Disabled; Complex; Computer Simulation; Condition; Consumption; Coupling; Custom; Data; Development; Device Designs; Devices; Diagnostic; Effectiveness; Electrodes; Electroencephalography; Electromagnetic Energy; Event; Foundations; Frequencies; Future; Goals; Human; Hybrids; In Vitro; Investigation; Lead; Length; Life; Link; Microelectrodes; Miniaturization; Modeling; Nature; Nervous system structure; Neurologic; Neurosciences; Operative Surgical Procedures; Performance; Peripheral Nervous System; Pilot Projects; Placement; Property; Public Health; Radiation; Radio; Range; Rattus; Rehabilitation therapy; Research; Research Personnel; Resort; Risk; Saline; Signal Transduction; Silicon; Surface; System; Techniques; Technology; Telemetry; Testing; Tissues; User-Computer Interface; Vertebral column; Weight; Width; Wireless Technology; Work; analog; base; cranium; data acquisition; density; design; digital; direct application; implantable device; implantation; innovation; insight; microwave electromagnetic radiation; miniaturize; multidisciplinary; neuroprosthesis; novel strategies; prototype; relating to nervous system; research study; simulation; size; telemetering; tool

DESCRIPTION (provided by applicant): Pilot studies suggest a new approach to passive wireless biotelemetry for neural interfaces that may offer a breakthrough in size, weight, and power consumption. UHF band prototype devices involving only a very few active and passive components demonstrate the capability of an innovative back-scatter technology for telemetry of bioelectric events in 10 KHz bandwidths. In this project, we investigate the potential for a different paradigm in short range biotelemetry that achieves characteristics of small size and high performance not through silicon LSI techniques but by employing passive microwave circuits. Computer models using full wave electromagnetic simulations and nonlinear circuit analysis suggest that miniature devices designed for operation in the 5-10 GHz range can offer adequate levels of back-scattered signal and detectably transmit neuroelectric signals as low as 30 microvolts in amplitude. This suggests sufficient sensitivity for passive telemetry of cortical EEG and neural spike events. Miniature wireless neuroelectrodes will be made in this work using photolithographic tools and hybrid integration of commercial microwave components. This work will initially focus on demonstrating principles with a single channel device. We will characterize its sensitivity, range, and other qualities in-vitro using tissue-mimicking saline tanks. Implanted devices will wirelessly relay low level brain cortical potentials in acute experiments in rats. We will attempt to characterize and optimize the range and sensitivity performance of this approach for ultimate application to the more stringent radio frequency conditions of human implantation. This work will give insight into the potential for passive systems as a communications link for implantable multichannel neuroprostheses waveform data acquisition systems. This project is a step towards the long-sought goal of ultraminiature low power wireless devices directed towards high density wireless communication for neuroscience and neuroengineering investigators. PUBLIC HEALTH RELEVANCE This project seeks to develop a new type of RF-passive wireless biotelemetry system having the potential for high miniaturization and so suited to coupling to wholly implantable neuroelectrodes. This system uses microwave backscatter and the nonlinear properties of diodes for telemetry of biopotentials without resorting to complex analog or digital LSI techniques. We will investigate the effectiveness of this passive microwave telemetry device for transmitting neurological signals by designing and testing a prototype device that fits inside of a rat skull. Developments of the principles might eventually allow new designs of neuroprostheses useful in a wide variety of rehabilitation, clinical diagnostic, and man-machine interface applications.

描述（由申请人提供）：试点研究提出了一种用于神经接口的无源无线生物遥测的新方法，该方法可能在尺寸、重量和功耗方面取得突破。UHF波段的原型设备，只涉及很少的有源和无源组件展示了一种创新的反向散射技术的能力，在10千赫带宽的生物电事件的遥测。在这个项目中，我们研究了一个不同的模式，在短距离生物遥测，实现小尺寸和高性能的特点，而不是通过硅LSI技术，而是通过采用无源微波电路的潜力。使用全波电磁模拟和非线性电路分析的计算机模型表明，设计用于在5-10 GHz范围内操作的微型设备可以提供足够水平的反向散射信号，并可检测地传输幅度低至30微伏的神经电信号。这表明皮质EEG和神经尖峰事件的被动遥测具有足够的灵敏度。微型无线神经电极将在这项工作中使用微波工具和混合集成的商业微波组件。这项工作将首先集中在演示原理与单通道设备。我们将使用仿组织盐水罐在体外表征其灵敏度、范围和其他品质。在大鼠急性实验中，植入的装置将无线中继低水平的大脑皮层电位。我们将尝试表征和优化这种方法的范围和灵敏度性能，以最终应用于更严格的人体植入射频条件。这项工作将深入了解作为植入式多通道神经假体波形数据采集系统的通信链路的无源系统的潜力。这个项目是一个长期追求的目标，超小型低功耗无线设备，面向高密度无线通信的神经科学和神经工程研究人员。公共卫生相关性本项目旨在开发一种新型的射频无源无线生物遥测系统，该系统具有高度小型化的潜力，因此适合耦合到完全植入式神经电极。该系统使用微波后向散射和非线性特性的二极管遥测的生物电位，而不诉诸于复杂的模拟或数字大规模集成电路技术。我们将通过设计和测试一个适合老鼠头骨的原型设备来研究这种无源微波遥测设备传输神经信号的有效性。这些原则的发展可能最终允许新的神经假体设计，适用于各种康复，临床诊断和人机界面应用。