RHEOACOUSTIC IMAGING/BIOELECTRICITY MEASUREMENT METHOD

流变声成像/生物电测量方法

• 批准号: 3431789
• 负责人: BRUCE C. TOWE
• 金额: $ 3.28万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-09 至 1992-04-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3431789
• 关键词: biomedical equipment development; clinical biomedical equipment; model; nonblood rheology; noninvasive diagnosis; ultrasonography

It can be shown that the passage of ultrasonic waves through a tissue medium causes a previously unreported periodic modulation of the tissue resistance. If bioelectric currents are flowing in the sound path, amplitude modulation of the currents at the sound frequency rate have been observed. Using this effect, it may be possible to develop a type of noninvasive bioelectric current imaging modality which could be potentially very useful in medical diagnostics and electrophysiological research. This basic approach would in principle show physiologic function through visualization of biochemical electron exchange and ion transport phenomena rather than physical structure. This research proposes to examine the feasibility of developing such an instrument and identify the factors important in its operation. This will be accomplished through the use of tissue and gel models with artificially introduced ionic current flows. Measurement of acoustic wave interactions with the currents will be by surface biopotential electrodes and signal processing applied to extract location specific information concerning bioelectric current flows.

可以证明，超声波通过组织 介质引起先前未报道的组织的周期性调制 阻力 如果生物电流在声音路径中流动， 在声音频率速率下电流的幅度调制已经被 观察 利用这种效应，可能会开发出一种 非侵入性生物电流成像模式， 在医学诊断和电生理学中可能非常有用 research. 这种基本方法原则上显示出生理学的 功能通过可视化的生化电子交换和离子 物理现象而不是物理结构。 本研究旨在探讨开发此类产品的可行性 工具，并确定其运作中的重要因素。 这将 通过使用组织和凝胶模型， 引入离子电流。 声波相互作用的测量 与电流将通过表面生物电位电极和信号 应用于提取位置特定信息的处理，该位置特定信息涉及 生物电流流动。