Wireless Ultrasound Biotelemetry

无线超声生物遥测

• 批准号: 7512970
• 负责人: BRUCE C. TOWE
• 金额: $ 20.02万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7512970
• 关键词: Address; Adopted; Animals; Be++ element; Beryllium; Body Surface; Brain; Cellular Phone; Characteristics; Clinical; Communication; Complex; Condition; Custom; Data; Depth; Development; Devices; Diagnostic; Distributed Systems; Effectiveness; Electrodes; Event; Foundations; Frequencies; Future; Generations; Goals; Human; Image; Imaging technology; Implant; In Vitro; Investigation; Link; Maps; Measures; Methods; Modeling; Modification; Muscle; Nature; Needles; Nerve; Nervous system structure; Neurologic; Numbers; Performance; Peripheral Nervous System; Physiologic pulse; Polymers; Process; Public Health; Pulse taking; Range; Rattus; Rehabilitation therapy; Relative (related person); Reporting; Research; Research Personnel; Risk; Saline; Scanning; Semiconductors; Sensory; Series; Signal Transduction; Skin; Surface; Syringes; System; Techniques; Technology; Telemetry; Testing; Time; Tissues; Transducers; Trauma; Ultrasonic Therapy; Ultrasonics; Ultrasonography; User-Computer Interface; Vertebral column; Weight; Wireless Technology; Work; cranium; design; direct application; experience; implantable device; implantation; insight; interest; millimeter; neuroprosthesis; novel strategies; pressure; prototype; relating to nervous system; size; success; telemetering

DESCRIPTION (provided by applicant): This project investigates a possible new method of creating multichannel wireless interfaces to the nervous system which depends on the use of ultrasound energy as a means of power and communication with microsized implants. The approach employs implantable microdevices of approximately 1.5 mm x 3 mm in size potentially delivered to tissues through a syringe needle. These act as ultrasonically powered bioelectric transponders of extremely simple design. We will evaluate these for wireless recording of bioelectrical events in brain and for potential application to spine, nerve and muscle. The project depends on an unexpected process whereby actively driven carrier frequency from the skin experiences intermodulation by bioelectric events at the interface of an implanted semiconductor junction diode. Bioelectrical signals are encoded on a volume conducted carrier wave generated by an ultrasound pressure wave on an integrated piezoelectric polymer. Bioelectric waveforms are remotely recorded by demodulating volume conducted carrier waves to surface biopotential electrodes. We will investigate the potential for short range biotelemetry that appears to have the potential for large scale multichannel capability in combination with principles of transit time range determination common to ultrasound imaging systems. This approach suggests a technology leading to bioelectric waveform mapping using implanted microdevices as a type of transponder. Implant prototypes have been constructed using simple modifications of commercially available semiconductor devices powered by a small integrated piezoelectric element that is actuated by ultrasound energy emitted from a skin transducer. We will characterize its sensitivity, range, and other qualities in-vitro using tissue-mimicking saline tanks then progress to rat models to measure brain field potentials events at 2 KHz bandwidths. We will attempt to characterize and optimize the range and sensitivity performance of this approach for ultimate application to the more stringent conditions of human implantation. This work will give insight into the potential for ultrasound driven systems as a communications link for implantable neuroprostheses. Project success should allow investigators to adopt such technology in relatively short time frame using commercially available components and without the use of complex custom integrated circuitry for implants. This approach appears to hold the potential for dramatic reductions in size, weight, and complexity of neural interfaces and may enable a new generation of brain and nervous system recording devices. PUBLIC HEALTH RELEVANCE: This project investigates a possible new method of creating multichannel wireless interfaces to the nervous system which depends on the use of ultrasound energy as a means of power and communication with microsized implants. The approach employs implantable microdevices of approximately 1.5 mm x 3 mm in size potentially delivered to tissues through a syringe needle. These act as ultrasonically powered bioelectric transponders of extremely simple design. The research will examine the performance and sensitivity characteristics that might allow them to be used in large numbers in multichannel application for bioelectrical waveform mapping in the volume of tissues. The work has potential application to neurosprothestics for the brain, spine, sensory, and peripheral nervous systems. We will investigate the effectiveness of this passive telemetry technique for transmitting neurological signals by designing and testing a prototype device that fits inside of a rat skull. Developments of the principles might eventually allow new designs of neuroprostheses useful in a wide variety of rehabilitation, clinical diagnostic, and man-machine interface applications.

描述（由申请人提供）：该项目研究了一种可能的新方法，该方法可以创建神经系统的多通道无线接口，该接口依赖于使用超声波能量作为微型植入物的动力和通信手段。该方法采用可植入的微型装置，尺寸约为1.5 mm x 3 mm，可能通过注射器针头输送到组织中。这些装置就像超声波驱动的设计极其简单的生物电转发器。我们将评估这些无线记录大脑的生物电事件和潜在的应用在脊柱，神经和肌肉。该项目依赖于一个意想不到的过程，即通过植入半导体结二极管界面上的生物电事件，皮肤上主动驱动的载流子频率经历互调。将生物电信号编码在集成压电聚合物上的超声压力波产生的体积传导载波上。通过解调体积传导载波到表面生物电位电极来远程记录生物电波形。我们将研究短程生物遥测的潜力，它似乎具有大规模多通道能力的潜力，结合超声成像系统常见的传输时间范围确定原理。这种方法提出了一种利用植入的微设备作为一种应答器来绘制生物电波形图的技术。植入原型是通过对市售半导体器件的简单修改而构建的，该器件由皮肤换能器发射的超声能量驱动的小型集成压电元件供电。我们将在体外使用模拟组织的生理盐水槽来表征其灵敏度、范围和其他品质，然后进行大鼠模型，以测量2khz带宽下的脑场电位事件。我们将尝试表征和优化该方法的范围和灵敏度性能，以便最终应用于更严格的人体植入条件。这项工作将深入了解超声驱动系统作为植入式神经假体通信链路的潜力。项目的成功应该允许研究人员在相对较短的时间内采用这种技术，使用市售组件，而不使用复杂的定制集成电路植入物。这种方法似乎有可能大幅减少神经接口的尺寸、重量和复杂性，并可能使新一代的大脑和神经系统记录设备成为可能。