Advancing UAF SNRP

阿拉斯加州与世隔绝和极端的自然条件为阿拉斯加大学费尔班克斯（UAF）提供了 神经科学家和他们的合作者有机会探索影响许多独特的健康问题， 阿拉斯加和北极的原住民。SNRP I项目专注于神经保护和适应的主题， 从细胞和分子的角度来探讨神经科学问题。SNRP II提案旨在 继续并加强这一主题，提出项目，检查神经控制的系统，细胞和 分子水平。该SNRP II合作协议提案基于UAF SNRP I取得的进展 在过去的四年里。2名神经科学教员的成功任期和为其他人提供的培训 教师，验证了最初的前提，高质量的基础研究导致教师和 神经科学专业的学生。我们的四个目标为UAF的持续增长提供了框架 SNRP计划：（1）启动新的研究计划，加强神经元适应和控制的主题， 系统、细胞和分子水平。(2)加强行政核心，从而确保 研究环境。(3)加强神经科学研究生教育 基础设施演进(4)扩大神经科学研究的本科生机会。 建议设立一个由科学主任和副主任组成的新的行政结构， 项目负责人负责提案的制定。该计划咨询委员会将监测该计划;科学 咨询委员会将讨论结果，并向项目负责人提出未来的研究方向，目标是 增加教师研究经费。主要项目探讨血清素在控制和神经调节中的作用， 行为的受体水平。小型项目被提议为未来的NIH提案生成数据， UAF教师和学生参与SNRP。SNRP II提供的扩展研究机会将 鼓励阿拉斯加原住民学生积极参与项目，并将增加阿拉斯加学生的数量。 本地学生活跃于基于假设的神经科学研究。

The isolation and extreme natural conditions inherent in Alaska provide University of Alaska Fairbanks (UAF) neuroscientists and their collaborators an opportunity to explore a variety of health issues affecting the many unique Native Alaskan and Arctic populations. Focused on a theme of neuroprotection and adaptation, the SNRP I program approached neuroscience questions from a cellular and molecular perspective. The SNRP II proposal seeks to continue and strengthen this theme by proposing projects that examine neural control at the system, cellular and molecular levels. This SNRP II cooperative agreement proposal is based on the progress achieved by UAF SNRP I over the last four years. The successful tenure of 2 neuroscience faculty members and the training provided to other faculty, validates the initial premise that high quality basic research leads to increased opportunities for faculty and students in the neurosciences at UAF. Our four aims provide the framework for the continued growth of the UAF SNRP program: (1) To initiate new research programs strengthening the theme of neuronal adaptation and control at the system, cellular and molecular levels. (2) To strengthen the administrative core thereby ensuring a more effective research environment. (3) To emphasize graduate neuroscience education by strengthening the educational infrastructure. (4) To expand undergraduate opportunities for neuroscience research. A new administrative structure consisting of a Scientific Director and Associate Director is proposed to counsel project leaders on proposal development. The Program Advisory Committee will monitor the program; a Scientific Advisory Committee will discuss results and suggest future research directions to the project leaders with the goal of increasing faculty research funding. Major projects explore the role of serotonin in control and neuromodulation from the level of receptor to behavior. Small projects are proposed to generate data for future NIH proposals and increase UAF faculty and student involvement in SNRP. The expanded research opportunities offered by SNRP II will stimulate the active participation of Alaskan Native students in the projects and will increase the number of Alaskan Native students active in hypothesis-based neuroscience research.