Advancing UAF SNRP

阿拉斯加与世隔绝和极端的自然条件为阿拉斯加大学费尔班克斯分校(UAF) 神经学家和他们的合作者有机会探索影响许多独特的各种健康问题 阿拉斯加和北极的原住民。重点关注神经保护和适应的主题，SNRP I方案 从细胞和分子的角度探讨神经科学问题。SNRP II提案旨在 继续并加强这一主题，提出检查系统、细胞和 分子水平。该SNRP II合作协议提案是基于UAF SNRP I取得的进展 在过去四年里。2名神经科学教员的成功任职和为其他人提供的培训 证实了高质量的基础研究为教职员工带来更多机会这一初始前提 UAF神经科学专业的学生。我们的四个目标为UAF的持续发展提供了框架 SNRP方案：(1)启动新的研究方案，加强神经元适应和控制的主题 系统、细胞和分子水平。(2)加强行政核心，确保更有效的 研究环境。(3)加强研究生神经科学教育 基础设施。(4)扩大本科生神经科学研究机会。 建议设立一个新的行政结构，由一名科学主任和一名副主任组成，负责法律顾问 项目负责人对提案的开发。计划咨询委员会将监督该计划；一个科学的 咨询委员会将讨论结果并向项目负责人建议未来的研究方向，目标是 增加教职员工研究经费。主要项目探索5-羟色胺在控制和神经调节中的作用 行为的感受器水平。小型项目被提出，为未来的NIH提案生成数据，并增加 UAF教职员工和学生参与SNRP。SNRP II提供的更多研究机会将 鼓励阿拉斯加原住民学生积极参与项目，并将增加阿拉斯加人的数量 活跃于基于假设的神经科学研究的本地学生。

The isolation and extreme natural conditions inherent in Alaska provide University of Alaska Fairbanks (UAF) neuroscientists and their collaborators an opportunity to explore a variety of health issues affecting the many unique Native Alaskan and Arctic populations. Focused on a theme of neuroprotection and adaptation, the SNRP I program approached neuroscience questions from a cellular and molecular perspective. The SNRP II proposal seeks to continue and strengthen this theme by proposing projects that examine neural control at the system, cellular and molecular levels. This SNRP II cooperative agreement proposal is based on the progress achieved by UAF SNRP I over the last four years. The successful tenure of 2 neuroscience faculty members and the training provided to other faculty, validates the initial premise that high quality basic research leads to increased opportunities for faculty and students in the neurosciences at UAF. Our four aims provide the framework for the continued growth of the UAF SNRP program: (1) To initiate new research programs strengthening the theme of neuronal adaptation and control at the system, cellular and molecular levels. (2) To strengthen the administrative core thereby ensuring a more effective research environment. (3) To emphasize graduate neuroscience education by strengthening the educational infrastructure. (4) To expand undergraduate opportunities for neuroscience research. A new administrative structure consisting of a Scientific Director and Associate Director is proposed to counsel project leaders on proposal development. The Program Advisory Committee will monitor the program; a Scientific Advisory Committee will discuss results and suggest future research directions to the project leaders with the goal of increasing faculty research funding. Major projects explore the role of serotonin in control and neuromodulation from the level of receptor to behavior. Small projects are proposed to generate data for future NIH proposals and increase UAF faculty and student involvement in SNRP. The expanded research opportunities offered by SNRP II will stimulate the active participation of Alaskan Native students in the projects and will increase the number of Alaskan Native students active in hypothesis-based neuroscience research.