Advancing UAF SNRP

阿拉斯加固有的与世隔绝和极端自然条件为阿拉斯加大学费尔班克斯分校 (UAF) 提供了条件 神经科学家及其合作者有机会探索影响许多独特的健康问题 阿拉斯加和北极地区的原住民。 SNRP I 计划以神经保护和适应为主题 从细胞和分子的角度探讨神经科学问题。 SNRP II 提案旨在 通过提出检查系统、细胞和神经控制的项目来继续并加强这一主题。 分子水平。该SNRP II合作协议提案是基于UAF SNRP I所取得的进展 在过去的四年里。 2 名神经科学教员的成功任职以及为其他人员提供的培训 验证了最初的前提，即高质量的基础研究可以增加教师和教师的机会 UAF 神经科学专业的学生。我们的四个目标为 UAF 的持续发展提供了框架 SNRP 计划：(1) 启动新的研究计划，加强神经元适应和控制的主题 系统、细胞和分子水平。 （二）强化行政核心，提高行政效能 研究环境。 （三）强化研究生神经科学教育 基础设施。 (4)扩大本科生进行神经科学研究的机会。 建议设立一个由科学主任和副主任组成的新行政结构，以提供咨询 项目负责人负责提案的制定。项目咨询委员会将监督该项目；科学的 顾问委员会将讨论结果并向项目负责人建议未来的研究方向，目标是 增加教师研究经费。主要项目探索血清素在控制和神经调节中的作用 行为受体的水平。建议小型项目为未来的 NIH 提案生成数据并增加 UAF 教职员工和学生参与 SNRP。 SNRP II 提供的扩展研究机会将 刺激阿拉斯加原住民学生积极参与项目，并将增加阿拉斯加原住民学生的数量 本地学生积极从事基于假设的神经科学研究。

The isolation and extreme natural conditions inherent in Alaska provide University of Alaska Fairbanks (UAF) neuroscientists and their collaborators an opportunity to explore a variety of health issues affecting the many unique Native Alaskan and Arctic populations. Focused on a theme of neuroprotection and adaptation, the SNRP I program approached neuroscience questions from a cellular and molecular perspective. The SNRP II proposal seeks to continue and strengthen this theme by proposing projects that examine neural control at the system, cellular and molecular levels. This SNRP II cooperative agreement proposal is based on the progress achieved by UAF SNRP I over the last four years. The successful tenure of 2 neuroscience faculty members and the training provided to other faculty, validates the initial premise that high quality basic research leads to increased opportunities for faculty and students in the neurosciences at UAF. Our four aims provide the framework for the continued growth of the UAF SNRP program: (1) To initiate new research programs strengthening the theme of neuronal adaptation and control at the system, cellular and molecular levels. (2) To strengthen the administrative core thereby ensuring a more effective research environment. (3) To emphasize graduate neuroscience education by strengthening the educational infrastructure. (4) To expand undergraduate opportunities for neuroscience research. A new administrative structure consisting of a Scientific Director and Associate Director is proposed to counsel project leaders on proposal development. The Program Advisory Committee will monitor the program; a Scientific Advisory Committee will discuss results and suggest future research directions to the project leaders with the goal of increasing faculty research funding. Major projects explore the role of serotonin in control and neuromodulation from the level of receptor to behavior. Small projects are proposed to generate data for future NIH proposals and increase UAF faculty and student involvement in SNRP. The expanded research opportunities offered by SNRP II will stimulate the active participation of Alaskan Native students in the projects and will increase the number of Alaskan Native students active in hypothesis-based neuroscience research.