Advancing UAF SNRP

描述(由申请者提供)：阿拉斯加与世隔绝的极端自然条件为阿拉斯加大学费尔班克斯分校提供了 (UAF)神经科学家及其合作者有机会探索各种影响健康的问题 许多独特的阿拉斯加和北极原住民。重点关注神经保护和 适应，SNRP I计划从细胞和分子角度探讨神经科学问题 透视。SNRP II提案寻求通过提出以下项目来继续和加强这一主题 在系统、细胞和分子水平上检查神经控制。本SNRP II合作协议 该提案是根据UAF SNRP I在过去4年中取得的进展提出的。他的成功任期 2名神经科学教员和向其他教员提供的培训验证了最初的 高质量的基础研究为教职员工和学生带来更多的机会 UAF的神经科学专业。我们的四个目标为UAF SNRP的持续发展提供了框架 计划：(1)启动新的研究计划，加强神经元适应和控制的主题 在系统、细胞和分子水平上。(2)加强行政核心，从而确保 更有效的研究环境。(三)加强研究生神经科学教育 加强教育基础设施建设。(四)拓展本科生进修神经科学的机会 研究。 提议设立一个由1名科学主任和1名副主任组成的新行政结构，以 为项目负责人提供建议书开发方面的咨询。杰出的资深科学家将担任 计划咨询委员会(PAC)和科学咨询委员会(SAC)提供建议 关于规划和研究方向。重大项目探索5-羟色胺在动态平衡中的作用。这个 SNRP II提供的更多研究机会将刺激阿拉斯加原住民的积极参与 项目中的学生，并将增加活跃在假设基础上的阿拉斯加原住民学生的数量 神经科学研究。

Description (provided by applicant): The isolation and extreme natural conditions inherent in Alaska provide University of Alaska Fairbanks (UAF) neuroscientists and their collaborators an opportunity to explore a variety of health issues affecting the many unique Native Alaskan and arctic populations. Focused on a theme of neuroprotection and adaptation, the SNRP I program approached neuroscience questions from a cellular and molecular perspective. The SNRP II proposal seeks to continue and strengthen this theme by proposing projects that examine neural control at the system, cellular and molecular levels. This SNRP II cooperative agreement proposal is based on the progress achieved by UAF SNRP I over the last 4 years. The successful tenure of 2 neuroscience faculty members and the training provided to other faculty members validates the initial premise that high quality basic research leads to increased opportunities for faculty and students in the neurosciences at UAF. Our four aims provide the framework for the continued growth of the UAF SNRP program: (1) To initiate new research programs strengthening the theme of neuronal adaptation and control at the system, cellular and molecular level. (2) To strengthen the administrative core thereby ensuring a more effective research environment. (3) To emphasize graduate neuroscience education by strengthening the educational infrastructure. (4) To expand undergraduate opportunities for neuroscience research. A new administrative structure consisting of a Scientific Director and Associate Director is proposed to counsel project leaders on proposal development. Outstanding senior scientists will serve as advisors on Program Advisory Committee (PAC) and Scientific Advisory Committee (SAC) to provide recommendations regarding program and research direction. Major projects explore the role of serotonin in homeostasis. The expanded research opportunities offered by SNRP II will stimulate the active participation of Alaska Native students in the projects and will increase the number of Alaskan Native students active in hypothesis-based neuroscience research.