Washington University Molecular Imaging Center

描述（由申请人提供）： 华盛顿大学医学院的体内细胞和 分子成像中心（ICMIC）设想了一个过程，将允许 中心成为开发新颖活体的焦点 分子成像实验这涉及到进一步扩大和 加强合作，提高多学科的生产力 基础癌细胞生物学和分子成像研究项目。的 P50计划的最终目标是将联合收割机的机构 华盛顿大学在分子生物学基础科学方面的专业知识 肿瘤学、免疫学、分子遗传学和信号转导 在正式配置下， 一个ICMIC。我们的战略定位是将我们的大部分ICMIC 关于新型互动和协作肿瘤学进展的资源 分子成像项目。为了实现这些目标，组织结构 拥有三个分子成像核心，四个多学科ICMIC研究 项目，四个发展研究项目，一个教育计划和一个 培训/职业发展计划。这四个项目， 代表校园创新和令人兴奋的新举措是：1）在 前列腺癌基因表达的体内成像，2）非侵入性 T细胞介导的肿瘤消融的监测，3）用 达特可转导肽，4）成像MDRI P-糖蛋白转运活性 在体内用Tc-94 m-Sestamibi PET预测化疗反应 小细胞肺癌的早期症状一种组织结构， ICMIC已经建立，我们积极的P20实现了所有里程碑 规划补助金。P50中心赠款现在将促进卓越的分子 通过提供跨学科的正式渠道， 多模式合作。

DESCRIPTION (provided by applicant): Washington University Medical School's concept of an In Vivo Cellular and Molecular Imaging Center (ICMIC) envisions a process that will permit the Center to become the focal point for the development of novel in vivo molecular imaging initiatives on campus. This involves further expanding and reinforcing collaborations and enhancing the productivity of multidisciplinary programs in basic cancer cell biology and molecular imaging research. The ultimate objective of the proposed P50 Program is to combine the institutional expertise of Washington University in the basic sciences of molecular oncology, immunology, molecular genetics and signal transduction with our well developed infrastructure in medical imaging under the formal configuration of an ICMIC. We are strategically positioned to focus the majority of our ICMIC resources on the advancement of novel interactive and collaborative oncologic molecular imaging projects. To meet these goals, an organizational structure with three molecular imaging cores, four multidisciplinary ICMIC research projects, four developmental research projects, an educational program and a training/career development program are proposed. The four projects, representing innovative and exciting new initiatives on campus are: 1) In Vivo Imaging of Gene Expression in Prostate Cancer, 2) Non-Invasive Monitoring of T Cell-Mediated Tumor Ablation, 3) Imaging Cancer Viruses with Tat Transducible Peptides, 4) Imaging MDRI P-glycoprotein Transport Activity In Vivo with Tc-94m-Sestamibi PET to Predict Response to Chemotherapy in Extensive Stage Small Cell Lung Cancer. An organizational structure for an ICMIC has been established and all milestones achieved with our active P20 planning grant. The P50 Center grant will now promote excellence in molecular imaging in cancer research by providing a formal conduit for interdisciplinary multi-modality collaborations.