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Immediate Hypersensitivity Responses--control In Parasit

Immediate Hypersensitivity Responses--control In Parasit
立即超敏反应——寄生虫的控制
批准号：
6986439
负责人：
THOMAS B NUTMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6986439
关键词：
cytokineenzyme linked immunosorbent assayeosinophiliafilariasisflow cytometryhuman subjectimmediate hypersensitivityimmunoglobulin Einflammationlaboratory mousenucleic acid sequenceparasitic diseasespolymerase chain reactiontissue /cell culture

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中文摘要
翻译
高嗜酸性粒细胞增多的情况已经被广泛研究，我们已经确定了区分骨髓增生性和淋巴增生性高嗜酸性粒细胞综合征的新标记物。在进行了这一区分之后，我们已经制定了新的治疗方法(伊马替尼、抗IL5)来治疗这些类型的每一种。利用流行病学工具，结合过敏性疾病的生理测量和免疫学评估，研究了蠕虫感染和过敏性疾病之间的相互作用。我们已经证明，慢性蠕虫感染可以预防过敏性疾病。
英文摘要
Hypereosinophilic conditions have been studied extensively, and we have identified new markers that distinguish between a myeloproliferative and a lymphoproliferative form of the Hyperosinophilic Syndrome. Having made this distinction, we have instituted new therapies (imatinib, anti-IL5) for the treatment of each of these forms. The interaction between helminth infeciton and allergic disease has been studied using epidemiological tools coupled with physiological measurements of allergic disease and immunological assessments. We have demonstrated that chronic helminth infection protects against allergic diseases.
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CLINICAL AND THERAPEUTIC STUDIES OF HUMAN FILARIASIS
CLINICAL AND THERAPEUTIC STUDIES OF HUMAN FILARIASIS
Clinical And Therapeutic Studies Of Human Filariasis
Immunoregulation /immune Recognition In Filarial/nonfila
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