Immediate Hypersensitivity Responses--control In Parasit

嗜酸性粒细胞增多症已被广泛研究，我们已经确定了新的标志物，区分这种综合征的几个重要变种。我们已经制定了新的疗法（伊马替尼，抗IL-5）治疗这些变异。 蠕虫感染和过敏性疾病之间的相互作用已经研究了流行病学的工具，加上过敏性疾病的生理测量和免疫学评估。我们已经证明，慢性蠕虫感染可以预防过敏性疾病。迄今为止所做的研究已经证明，在慢性丝虫感染中，CD 4+细胞（而不是单核细胞或嗜碱性粒细胞）是IL-10的压倒性主要来源。我们还证明，即使在没有抗原刺激的情况下，IgE介导的应答也持续数十年。

Hypereosinophilic conditions have been studied extensively, and we have identified new markers that distinguish between several important variants of this syndrome. We have instituted new therapies (imatinib, anti-IL5) for the treatment of each of these variants. The interaction between helminth infeciton and allergic disease has been studied using epidemiological tools coupled with physiological measurements of allergic disease and immunological assessments. We have demonstrated that chronic helminth infection protects against allergic diseases. Studies done to date have demonstrated the CD4+ cells (and neither the monocytes nor the basophils) are the overwhelmingly major source of IL-10 in chronic filarial infection. We have also demonstrated that IgE mediated responses persist for decades even in the absence of antigen stimulation.