Immediate Hypersensitivity Responses--control In Parasit

立即超敏反应——寄生虫的控制

• 批准号: 7302672
• 负责人: THOMAS B NUTMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7302672
• 关键词: Immediate; Hypersensitivity; Responses; control; Parasit

Hypereosinophilic conditions have been studied extensively, and we have identified new markers that distinguish between several important variants of this syndrome. We have instituted new therapies (imatinib, anti-IL5) for the treatment of each of these variants. The interaction between helminth infeciton and allergic disease has been studied using epidemiological tools coupled with physiological measurements of allergic disease and immunological assessments. We have demonstrated that chronic helminth infection protects against allergic diseases. Studies done to date have demonstrated the CD4+ cells (and neither the monocytes nor the basophils) are the overwhelmingly major source of IL-10 in chronic filarial infection. We have also demonstrated that IgE mediated responses persist for decades even in the absence of antigen stimulation.

高嗜酸性粒细胞增多症已经得到了广泛的研究，我们已经确定了区分这种综合征的几个重要变体的新标记物。我们已经制定了新的治疗方法(伊马替尼、抗IL5)来治疗这些变体。 利用流行病学工具，结合过敏性疾病的生理测量和免疫学评估，研究了蠕虫感染和过敏性疾病之间的相互作用。我们已经证明，慢性蠕虫感染可以预防过敏性疾病。到目前为止的研究已经证明，在慢性丝虫感染中，CD4+细胞(既不是单核细胞，也不是嗜碱性粒细胞)是IL-10的压倒性主要来源。我们还证明，即使在没有抗原刺激的情况下，IgE介导的反应也会持续数十年。