课题基金 / 基金详情

Clinical And Therapeutic Studies Of Human Filariasis

Clinical And Therapeutic Studies Of Human Filariasis
人类丝虫病的临床和治疗研究
批准号：
6808178
负责人：
THOMAS B NUTMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6808178
关键词：
Filarioidae adolescence (12-20) anthelmintics biopsy blood /lymphatic pharmacology chemokine clinical research clinical trials cytokine drug adverse effect enzyme linked immunosorbent assay eosinophil epidemiology filariasis human subject human therapy evaluation immunocytochemistry onchocerciasis parasitic disease chemotherapy parasitic disease diagnosis pathologic process polymerase chain reaction strongyloidiasis

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中文摘要
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英文摘要
Because the adverse reactions associated with treatment of onchocerciasis, loiasis, and lymphatic filariasis can be severe, systemic, and debilitating the mediators of this posttreatment reaction have been identified and quantified. In the acute phase (first 48 hours) an intracellular Wolbachia endosymbiont appears in the bloostream and is correlated with the presence of the inflmmatory mediators of the posttreatment adverse reactions. Later, the eosinophil plays a major role as do the chemokines associated with eosinophil trafficking.
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CLINICAL AND THERAPEUTIC STUDIES OF HUMAN FILARIASIS
CLINICAL AND THERAPEUTIC STUDIES OF HUMAN FILARIASIS
Immunoregulation /immune Recognition In Filarial/nonfila
MOLECULAR DEFINITION OF FILARIAL AND RELATED NONFILARIAL GENES AND PROTEINS