Design Of Immunogens

免疫原的设计

• 批准号: 6987285
• 负责人: Peter D Kwong
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6987285
• 关键词: AIDS vaccines; CD4 molecule; HIV envelope protein; HIV envelope protein gp120; SDS polyacrylamide gel electrophoresis; X ray crystallography; antigen antibody reaction; antigens; biomimetics; biotechnology; calorimetry; conformation; human immunodeficiency virus 1; human tissue; neutralizing antibody; physical model; protein engineering; protein folding; receptor binding; site directed mutagenesis; tissue /cell culture; transfection; vaccine development; virus receptors

Given our understanding of envelope-based mechanisms of humoral evasion, we have attempted to design envelope-based immunogens with these mechanisms disabled. Such modied immunogens with weakened defenses may elicit more broadly neutralizing antibodies.

鉴于我们对基于包膜的体液逃避机制的理解，我们试图设计基于包膜的免疫原，使这些机制失效。这种防御能力减弱的免疫原可能会引起更广泛的中和抗体。