Antibody Neutralization Mechanisms

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Highly effective neutralizing antibodies could have utility in the prevention or treatment of infection from HIV-1, malaria, and other human pathogens, including the recently emerged SARS-CoV-2. Much of our work with neutralizing antibodies has focused on identifying, characterizing and in many case improving naturally elicited antibodies. Improved HIV-1 neutralizing antibodies include versions of CD4-binding site-directed antibodies capable of neutralizing over 95% of HIV, and some of these have been manufactured and assessed clinically. We are also working in collaboration with other groups to identify and to characterize effective neutralizing antibodies against other human pathogens. Overall, our antibody-related work involves understanding and improving antibodies, as possible therapeutic agents against HIV-1, SARS-CoV-2, malaria and other human pathogens.