Antibody Neutralization Mechanisms

高效中和抗体可用于预防或治疗HIV-1、疟疾和其他人类病原体的感染，包括最近出现的SARS-CoV-2。我们在中和抗体方面的大部分工作都集中在识别、表征和在许多情况下改善自然引发的抗体上。改进的HIV-1中和抗体包括cd4结合位点定向抗体，能够中和95%以上的HIV，其中一些已经被制造出来并进行了临床评估。我们还与其他小组合作，确定和鉴定针对其他人类病原体的有效中和抗体。总的来说，我们的抗体相关工作包括了解和改进抗体，作为治疗HIV-1、SARS-CoV-2、疟疾和其他人类病原体的可能药物。

Highly effective neutralizing antibodies could have utility in the prevention or treatment of infection from HIV-1, malaria, and other human pathogens, including the recently emerged SARS-CoV-2. Much of our work with neutralizing antibodies has focused on identifying, characterizing and in many case improving naturally elicited antibodies. Improved HIV-1 neutralizing antibodies include versions of CD4-binding site-directed antibodies capable of neutralizing over 95% of HIV, and some of these have been manufactured and assessed clinically. We are also working in collaboration with other groups to identify and to characterize effective neutralizing antibodies against other human pathogens. Overall, our antibody-related work involves understanding and improving antibodies, as possible therapeutic agents against HIV-1, SARS-CoV-2, malaria and other human pathogens.