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Design Of Immunogens

Design Of Immunogens
免疫原的设计
批准号：
7299829
负责人：
Peter D Kwong
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7299829
关键词：
DesignImmunogens

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中文摘要
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英文摘要
Based on our understanding of envelope-based mechanisms of humoral evasion, we have attempted to design envelope-based immunogens with these mechanisms disabled. Such modied immunogens with weakened defenses may elicit more broadly neutralizing antibodies. We have also devised scaffolding technology, as a means of presenting structural mimics of the epitopes of broadly neutralizing antibodies to assist in their re-elicitation.
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CAPRISA HIV-1 neutralizing antibodies: Harnessing ontogeny for immunogen design
Mechanisms Of Humoral Evasion
Computational Tools for Protein Crystallization and Structural Analysis
Design Of Immunogens
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