Antibody Neutralization Mechanisms

高效的中和抗体可用于预防或治疗艾滋病毒-1、疟疾和其他人类病原体的感染。我们在HIV-1中和抗体方面的大部分工作都集中在识别、表征和在许多情况下改进自然诱导的抗体。改进的抗体包括能够中和超过95%的艾滋病毒的CD4结合位点定向抗体的版本。最近，我们发现了CD4结合位点抗体的改变，这种改变增强了抗体的效力，降低了多反应性。其他CD4结合部位抗体正在制造中，并在临床上进行评估。我们还与其他组织合作，确定针对其他高度不同的人类病原体的广泛中和抗体；具体地说，我们还分析了疫苗受试者中具有广泛阻断诺沃克病毒的抗体和具有广泛中和活性的甲型流感病毒抗体。因此，我们与抗体相关的工作包括了解和改进抗体，作为针对HIV-1和其他人类病原体的可能的治疗剂。

Highly effective neutralizing antibodies could have utility in the prevention or treatment of infection from HIV-1, malaria, and other human pathogens. Much of our work with HIV-1-neutralizing antibodies has focused on identifying, characterizing and in many case improving naturally elicited antibodies. Improved antibodies include versions of CD4-binding site-directed antibodies capable of neutralizing over 95% of HIV. Recently, we developed alterations of CD4-binding site antibodies which have increased potency and reduced polyreactivity. Other CD4-binding site antibodies are being manufactured and assessed clinically. We are also working in collaboration with other groups to identify broadly neutralizing antibodies against other highly diverse human pathogens; specifically, we have also analyzed vaccinees for antibodies with broad blockade against norovirus and for antibodies with broadly neutralizing activity against influenza A virus. Thus our antibody-related work involves understanding and improving antibodies, as possible therapeutic agents against HIV-1 and other human pathogens.