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Mechanisms Of Humoral Evasion

Mechanisms Of Humoral Evasion
体液逃避的机制
批准号：
8745617
负责人：
Peter D Kwong
金额：
$83.55万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8745617
关键词：
AntibodiesGlycoproteinsGoalsHIV-1ImmuneImmune responseInfectionLearningLicensingMasksMethodsPalivizumabPolysaccharidesRespiratory syncytial virusStructureTimeVaccine DesignVaccinesVirusbasedesignneutralizing antibodyprophylacticresponse

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中文摘要
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英文摘要
The HIV-1 envelope contains multiply overlapping (and redundant) mechanisms of humoral immune defence. These including glycan shielding, conformational masking, and immunodominant decoys with variable loops. Although explored extensively, many of these mechanisms are still only partially understood. We are using structure-based methods to define them further. In addition, we are examining the fusion glycoprotein from respiratory syncytial virus, to understand its mechanisms of humoral evasion.
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CAPRISA HIV-1 neutralizing antibodies: Harnessing ontogeny for immunogen design
Mechanisms Of Humoral Evasion
Computational Tools for Protein Crystallization and Structural Analysis
Design Of Immunogens
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