How does host cell influence HIV diversification?

宿主细胞如何影响HIV多样化？

• 批准号: nhmrc : 1025270
• 负责人: A/Pr Vanessa Venturi
• 金额: $ 32.83万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-host-cell-hiv-diversification/110422
• 关键词: How; does; host; cell; influence

HIV is a rapidly evolving virus, and within an infected individual it continually acquires new mutations and joins together mutations by recombination. We have developed a novel system for studying recombination, and find that different individuals have different recombination rates, which may contribute to why some individuals survive longer. This project aims to identify the mechanisms responsible for differing recombination rates and how we can alter these to improve patient outcome.

HIV是一种快速进化的病毒，在感染个体内，它不断获得新的突变并通过重组将突变结合在一起。我们已经开发了一种新的系统来研究重组，并发现不同的个体具有不同的重组率，这可能有助于为什么有些个体存活更长时间。该项目旨在确定导致不同重组率的机制，以及我们如何改变这些机制以改善患者的预后。