Viral antigen presentation kinetics and memory T cell inflation

人口老龄化是澳大利亚人口正在经历的重大变革之一，这将对健康产生重大影响。最近的研究表明，许多老年人表现出免疫风险表型(IRP)，其特征是免疫系统严重扭曲和人类巨细胞病毒(CMV)感染。在这个项目中，我们将研究CMV改变细胞免疫系统从而影响宿主对其他病原体免疫的机制。

The ageing of the population is one of the major transformations being experienced by Australia’s population which will have major health implications. Recent studies have shown that many elderly individuals display ‘immune risk phenotype’ (IRP) which is characterised by a severely distorted immune system and human cytomegalovirus (CMV) infection. In this project we will investigate the mechanisms by which CMV alters cellular immune system and thus impacts on the host immunity against other pathogens.