Viral antigen presentation kinetics and memory T cell inflation

病毒抗原呈递动力学和记忆 T 细胞膨胀

• 批准号: nhmrc : 1020323
• 负责人: A/Pr Vanessa Venturi
• 金额: $ 33.59万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/viral-antigen-presentation-cell-inflation/110020
• 关键词: Viral; antigen; presentation; kinetics; memory

The ageing of the population is one of the major transformations being experienced by Australia’s population which will have major health implications. Recent studies have shown that many elderly individuals display ‘immune risk phenotype’ (IRP) which is characterised by a severely distorted immune system and human cytomegalovirus (CMV) infection. In this project we will investigate the mechanisms by which CMV alters cellular immune system and thus impacts on the host immunity against other pathogens.

人口老龄化是澳大利亚人口正在经历的重大转变之一，将对健康产生重大影响。最近的研究表明，许多老年人表现出“免疫风险表型”（IRP），其特征是严重扭曲的免疫系统和人巨细胞病毒（CMV）感染。在这个项目中，我们将研究CMV改变细胞免疫系统的机制，从而影响宿主对其他病原体的免疫力。