Understanding T cell responses to infectious disease across the lifespan

了解 T 细胞在整个生命周期中对传染病的反应

• 批准号: nhmrc : GNT1067590
• 负责人: A/Pr Vanessa Venturi
• 金额: $ 44.78万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-t-cell-disease-lifespan/1344941
• 关键词: Understanding; cell; responses; infectious; disease

The effectiveness of immune responses to infectious diseases and vaccines declines during prolonged infection and is compromised in the very young and elderly. This research aims to better understand the compromise of the immune recognition and control of chronic infections and age-related defects in immunity. Such understanding is crucial to the development of strategies to improve the outcome of infections across the lifespan and the design of vaccines for chronic infections such as HIV.

在长期感染期间，对传染病和疫苗的免疫反应的有效性下降，并在幼儿和老年人中受到损害。本研究旨在更好地了解免疫识别和控制慢性感染和年龄相关免疫缺陷的妥协。这种理解对于制定改善整个生命周期感染结果的战略以及设计针对艾滋病毒等慢性感染的疫苗至关重要。