Understanding the impact of age and chronic infection on the T cell recognition and control of infectious disease

了解年龄和慢性感染对 T 细胞识别和控制传染病的影响

• 批准号: nhmrc : 1067590
• 负责人: A/Pr Vanessa Venturi
• 金额: $ 33.75万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-impact-age-infectious-disease/455315
• 关键词: Understanding; impact; age; chronic; infection

The effectiveness of immune responses to infectious diseases and vaccines declines during prolonged infection and is compromised in the very young and elderly. This research aims to better understand the compromise of the immune recognition and control of chronic infections and age-related defects in immunity. Such understanding is crucial to the development of strategies to improve the outcome of infections across the lifespan and the design of vaccines for chronic infections such as HIV.

在长期感染过程中，对传染病和疫苗的免疫反应的有效性会下降，并且在幼儿和老年人中会受到损害。这项研究旨在更好地了解慢性感染和与年龄相关的免疫缺陷的免疫识别和控制的妥协。这种理解对于制定改善整个生命周期感染结果的策略以及设计艾滋病毒等慢性感染的疫苗至关重要。