C-H Alkylation with Alcohols: Dual Catalytic C-H Alkylation using Alcohols as Electrophiles by Carbocation Promoted Oxidative Addition

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This research will develop the palladium-catalysed alkylation of C-H bonds using alcohols as the alkylating reagent. C-H functionalisation promises significant advantages in the construction of complex molecules avoiding pre-functionalisation. To date, C-H alkylation is less developed than other C-H functionalisation processes, and commonly relies on toxic alkyl halides. Here, a dual catalytic system will be developed to employ alcohols as alkylating agents. This work will expand the currently limited scope of C-H alkylation reactions, and avoid the requirement for activated alkyl halides. Reaction development (hit finding) and optimisation (DOE) will be performed with the aid of automation (Freeslate platforms in ROAR), to rapidly scope out the reaction space. Successful reactions will then be studied in detail for further insights. This project is co-funded by and in collaboration with AstraZeneca, and may include the possibility to undertake a placement.