CLINICAL CORE

临床核心负责维护一个特征良好的研究受试者库，以支持正常衰老、阿尔茨海默病（AD）、血管性痴呆（VD）和其他痴呆症的研究。它也是获取尸检同意书、成像数据和阿尔茨海默病中心统一数据集的重要资源。药理学计划是临床核心的一个组成部分。最后，临床核心作为EIT核心的临床医生的培训场所。临床核心的具体目标是：1）招募、评价和诊断患有轻度认知障碍和AD和VD所致痴呆的种族多样性受试者以及正常老年B对照; la）招募受试者并转诊至药理学项目进行临床试验; lb）将特征良好的受试者转诊至项目1（M Singh，PI）; lc）维持研究受试者登记（“池”）以支持其他ADRC附属研究项目; 2）对具有正常老化、轻度认知障碍（MCI）和AD痴呆的受试者进行重复临床评估和神经心理学测试（纵向研究）; 3）协调与研究受试者的关系（“协调”）。 尸检和生物组织项目的临床部分（病理学核心），包括获得尸检的知情同意书，维护相关临床数据，获得apoE基因分型的血液样本; 4）MRI档案的临床部分（成像核心）的协调; 5）向国家阿尔茨海默病协调中心（NACC）提交临床数据（数据管理核心）。指导的临床活动 对英语受试者的评估在临床核心中描述，而对西班牙语受试者的评估在西班牙语卫星（SSS）中描述。

The Clinical Core is responsible for maintaining a well-characterized pool of research subjects to support researcl in normal aging, Alzheimer disease (AD), vascular dementia (VD), and other dementias. It is also an essential resourc for obtaining autopsy consent, imaging data, and the Alzheimer Disease Center uniform data set. The Pharmacology Program is an integral component of the Clinical Core. Finally, the Clinical core serves as a training site for clinicians in the EIT core. The specific aims of the Clinical Core are: 1) Recruitment, evaluation, and diagnosis of ethnically-diverse subjects with mild cognitive impairment and dementia due to AD and VD, as well as normal elder b controls; la)Recruitment of subjects and referral to Pharmacology Program for clinical trials; lb) Referral of well-characterized subjects to Project #1 (M Singh, PI); lc) Maintenance of a research-subject registry ("pool") to support other ADRC affiliated research projects; 2) Repeat clinical evaluation and neuropsychological testing for subjects with normal aging, mild cognitive impairment (MCI) and AD dementia (Longitudinal Study); 3) Coordinatio_ of clinical components (with Pathology Core) of the Autopsy and Biological Tissue Program, including obtaining informed consent for autopsy, maintaining relevant clinical data, obtaining blood samples for apoE genotyping; 4) Coordination of the clinical components (with the Imaging Core) of an MRI Archive; 5) Submission of clinical data (with Data Management Core) to the National Alzheimer Coordinating Center (NACC). Clinical activities directed toward English-speaking subjects are described in the Clinical Core, while those for Spanish-speaking subjects are described in the Spanish Speaking Satellite (SSS).