EFFECTS OF ARTERIOSCLEROSIS ON BRAIN STRUCTURE AND FUNCTION

动脉硬化对脑结构和功能的影响

• 批准号: 7471178
• 负责人: HELENA Chang CHUI
• 金额: $ 7.55万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-15 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7471178
• 关键词: Accounting; Address; Alzheimer' s Disease; Alzheimer' s disease model; Amyloid; Arteries; Arterioloscleroses; Arteriosclerosis; Arts; Atherosclerosis; Atrophic; Autopsy; Blood Vessels; Brain; Brain Infarction; Brain Injuries; Cerebrovascular Disorders; Cerebrovascular Trauma; Cerebrum; Clinical; Cognition; Cognitive; Coupled; Data; Diagnosis; Dimensions; Disease; Dissociation; Epidemiologic Studies; Evolution; Goals; Health; Hemorrhage; Hippocampus (Brain); Image; Impaired cognition; Impairment; Infarction; Inflammatory; Ischemia; Laboratories; Learning; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Memory; Modality; Modeling; Multi-Infarct Dementia; Neuropsychology; Numbers; Pathology; Pathway interactions; Performance; Photography; Population; Prevention strategy; Principal Investigator; Process; Program Research Project Grants; Public Health; Recruitment Activity; Retinal; Risk; Risk Factors; Role; Sampling; Severities; Stroke; Structure; Testing; Thick; Venous; cardiovascular risk factor; cerebral atrophy; cognitive change; cognitive function; design; disability; executive function; gray matter; in vivo; intima media; neuroimaging; neuropathology; neuropsychological; novel; uptake; white matter; white matter change

This project addresses the overarching goals of the program project grant. The objective is to quantify the association between arteriosclerosis and changes in brain structure and function, taking into account measures of Alzheimer disease (AD) and cerebrovascular disease (CVD) pathology. Arteriosclerosis (AS) has well known relationships with ischemia, infarction, and hemorrhage and may have a role in the onset and progression of AD. However, our preliminary results suggest that AS has direct effects on brain parenchyma and hence cognition, independent of infarction and AD. We will explicitly evaluate alternate pathways by which arteriosclerosis can contribute to brain atrophy and cognitive impairment. Specific aim 1: In the autopsy subsample, we will quantify the association between cerebral cortical atrophy and executive function with the severity of arteriosclerosis, taking into account the severity of AD and CVD pathology. Specific aim 2: In the entire PPG sample, we will examine the relationship between arteriosclerosis and longitudinal change in cortical gray matter volume and executive cognitive function, using surrogate MRI measures to control for AD and CVD pathology. Specific aim 3: In exploratory analyses, we will evaluate the relationship between vascular risk profile and changes in brain structure and function. Specific aim 4: Finally, we will use all four modalities of vascular imaging, neuropsychology, MRI, and neuropathology to model the changes in AD and CVD pathology as a function of arteriosclerosis. The availability of longitudinal assessment with repeated quantitative neuroimaging and psychometrically-matched measures of cognition, together with neuropathology data, presents a unique opportunity to answer questions about how two major public health problems, AD and AS interact to cause brain injury and cognitive impairment.

该项目解决了项目赠款的总体目标。目标是量化 动脉硬化与大脑结构和功能变化之间的关联， 阿尔茨海默病（AD）和脑血管病（CVD）病理学的测量。动脉粥样硬化（AS） 与缺血、梗死和出血的关系是众所周知的， 和AD的进展。然而，我们的初步结果表明，AS对大脑有直接影响， 实质，因此认知，独立于梗死和AD。我们将显式地计算alternate 动脉硬化可能导致脑萎缩和认知障碍的途径。具体目标1： 在尸检子样本中，我们将量化大脑皮质萎缩与执行功能之间的关系。 功能与动脉硬化的严重程度，同时考虑到AD和CVD病理的严重程度。 具体目标2：在整个PPG样本中，我们将检查动脉硬化和动脉粥样硬化之间的关系。 皮质灰质体积和执行认知功能的纵向变化，使用替代MRI 控制AD和CVD病理的措施。具体目标3：在探索性分析中，我们将评估 血管风险状况与脑结构和功能变化之间的关系。具体目标4：最后， 我们将使用血管成像、神经心理学、MRI和神经病理学的所有四种模式来模拟 AD和CVD病理学的变化作为动脉硬化的函数。纵向的可用性 通过重复的定量神经成像和心理测量学匹配的认知测量进行评估， 与神经病理学数据一起，提供了一个独特的机会来回答关于两个主要的 公共卫生问题，AD和AS相互作用导致脑损伤和认知障碍。