Family Study of African Americans

非裔美国人的家庭研究

• 批准号: 6982838
• 负责人: kathleen r merikangas
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6982838
• 关键词: African American; alcoholism /alcohol abuse; anxiety disorders; behavioral /social science research tag; child behavior disorders; comorbidity; disease /disorder proneness /risk; family structure /dynamics; genetic susceptibility; human subject; psychopathology; socioenvironment; statistics /biometry

This was a five year study of black children ages 8-17 at high and low risk for alcohol-related problems based on a history of parental alcoholism. A prospective design was used to identify the specific disorders for which these children are at heightened vulnerability, and salient risk and protective processes in the development of the various types of childhood disorders. The major goals of the study were: 1. to examine the extent and patterns of psychopathology and behavioral problems among the offspring ages 8-17 of black alcoholic parents; 2. to assess the role of familial transmission of alcohol abuse/dependence and comorbid psychopathology, including substance abuse/dependence, in the pathogenesis of alcohol abuse in children; and 3. to identify multiple risk and protective indices of the pathogenesis of alcohol problems in black youth in order to yield information on the key targets of prevention and intervention. The key features of the study were: the sample of black alcohol abusers with young children about which there are sparse data; the epidemiologic source of the sample, which strengthened the generalizability of the findings and minimizes the bias in ascertainment of minorities from specialty treatment settings; the application of an epidemiologic family study paradigm, which permitted assessment of factors associated with familial transmission of risk factors and the mechanisms thereof; evaluation of the role of comorbidity of anxiety disorders and alcoholism in the transmission of alcohol-related problems; comprehensive assessment of vulnerability factors from broad domains or risk encompassing personal, family, and environmental attributes including community violence; the provision of knowledge essential for prevention through the assessment of protective factors which may inhibit pathogenic processes among children at high risk. Data collection of this study was completed at Yale University before the Principal Investigator?s relocation to the NIMH. The resources of our section have been devoted to preparation of these data for analysis and subsequent publications. This research provides a model for conducting studies of social epidemiology of mental disorders and substance abuse. During the past year, we have completed data cleaning and coding. The data are now ready for statistical analyses of the key study questions.

这是一项为期五年的研究，研究对象是8-17岁的黑人儿童，他们基于父母的酗酒史，患有酒精相关问题的风险很高和很低。一个前瞻性的设计被用来确定这些儿童处于高度脆弱性的具体疾病，并在发展中的各种类型的儿童疾病的显着风险和保护过程。 该研究的主要目标是： 1.研究8-17岁的黑人酗酒父母的后代的精神病理学和行为问题的程度和模式; 2.评估酒精滥用/依赖和共病精神病理学（包括药物滥用/依赖）的家庭传播在儿童酒精滥用发病机制中的作用;以及 3.确定黑人青年酒精问题发病机制的多种风险和保护指数，以获得关于预防和干预的关键目标的信息。 这项研究的主要特点是：对有年幼子女的黑人酗酒者进行抽样，这方面的数据很少;抽样的流行病学来源，这加强了调查结果的普遍性，并最大限度地减少了从专业治疗环境中确定少数群体的偏见;流行病学家庭研究范式的应用，其允许评估与危险因素的家庭传播相关的因素及其机制;评估焦虑症和酒精中毒的共病在酒精相关问题传播中的作用;全面评估广泛领域的脆弱性因素或风险，包括个人、家庭和环境特征，包括社区暴力;通过评估可能抑制高危儿童发病过程的保护性因素，提供预防所必需的知识。 本研究的数据收集是在耶鲁大学完成的，主要研究者？她搬到了NIMH。本节的资源用于准备这些数据，以供分析和随后的出版。这项研究为进行精神障碍和药物滥用的社会流行病学研究提供了一个模式。在过去的一年里，我们完成了数据清理和编码。数据现已准备好用于关键研究问题的统计分析。