Neurodevelopmental Genomics

在过去的一年里，7500名青年参加了这项研究，并接受了临床和医学访谈以及认知测试，750名青年完成了该项目的神经成像部分。NIMH和宾夕法尼亚大学的团队密切合作，开发诊断措施，开发算法，以识别有情绪和行为障碍风险的青少年，以及一系列医疗条件。目前正在NIMH网站进行更广泛的诊断访谈，以交叉验证这一评估。

During the past year, 7,500 youth have been enrolled in the study and undergone the clinical and medical interviews, and cognitive testing, and 750 have completed the neuroimaging component of the project. The NIMH and U Penn teams have worked closely in the development of the diagnostic measures, and in developing algorithms for identification of youth at risk for emotional and behavioral disorders, as well as a range of medical conditions. Cross validation of this assessment with more extensive diagnostic interviews at the NIMH site is now underway. Public Health Impact: The proposed comprehensive phenotyping will benefit medicine across diseases and include neurobehavioral measures, which will help elucidate both specific effects of neuropsychiatric disorders and the impact of other medical disorders on brain function. Future Plans: Enrollment of the study should be completed by the end of 2011, and the NIMH team will work with the U Penn and CHOP collaborators to develop plans for analyses of the data. In addition, NIMH is planning some nested case control studies of youth with mood disorders and migraine in the sample.